Annona atemoya Leaf Extract / neuroP Cancer Research Results

AAL, Annona atemoya Leaf Extract: Click to Expand ⟱
Features:

Annona atemoya Leaf Extract - Atemoya Leaf Extract

Alternative Names: Annona atemoya leaf extract, Atemoya leaf extract, AAL extract

Type: Botanical extract / polyphenol- and flavonoid-containing plant product

Source: Leaves of Annona atemoya, a hybrid of Annona squamosa and Annona cherimola.

Active Constituents: Reported constituents include rutin, isoquercitrin, other flavonoids, phenolic compounds, proanthocyanidins, and alkaloids. Rutin was the most abundant quantified compound in one Alzheimer’s disease-focused ethanol extract study, and both rutin and isoquercitrin inhibited amyloid-β aggregation.

Function: Annona atemoya leaf extract exhibits antioxidant, neuroprotective, anti-inflammatory, cholinergic, and antiproliferative activities in experimental models. Reported effects include reduction of reactive oxygen species and neuronal cell death, modulation of EGFR/GRK2 and Akt/CREB/BDNF signaling, and protection of cognitive function.

Cancer: Preclinical leaf-extract studies show antiproliferative activity against cancer cell lines including HeLa cervical cancer and HepG2 hepatocellular carcinoma cells. Activity has been associated particularly with alkaloid-containing fractions. Direct clinical anticancer efficacy has not been established.

Alzheimer's Disease: Preclinical evidence is relatively strong for a botanical extract. Annona atemoya leaf extract inhibits amyloid-β aggregation, reduces oxidative stress and neuronal cell death, and improves learning and memory in Aβ-induced Alzheimer's disease-like mouse models. Reported mechanisms include modulation of EGFR/GRK2 signaling and preservation of neuronal and neurotrophic signaling. It also improves cognitive impairment in scopolamine-treated mice through effects on cholinergic function, oxidative stress, Akt, CREB, and BDNF. Human clinical efficacy has not been established.
neuroP, neuroprotective: Click to Expand ⟱
Source:
Type:
Neuroprotective refers to the ability of a substance, intervention, or strategy to preserve the structure and function of nerve cells (neurons) against injury or degeneration.
-While cancer and neurodegenerative processes might seem distinct, there is significant overlap in terms of treatment-related neurotoxicity, shared molecular mechanisms, and the potential for therapies that provide neuroprotection during cancer treatment.
Scientific Papers found: Click to Expand⟱
7842- AAL,  ISQ,  RT,    Annona atemoya leaf extract ameliorates cognitive impairment in amyloid-β injected Alzheimer's disease-like mouse model
- in-vivo, AD, HT22
*Aβ↓, *ROS↓, *Apoptosis↓, *memory↑, *BDNF↓, *Dose↝, *neuroP↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Functional Outcomes(tgid=23) ⓘ

memory↑, 1,   neuroP↑, 1,  
Total Targets: 7

Scientific Paper Hit Count for: neuroP, neuroprotective
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:467  Target#:1105  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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