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| Ferulic acid is an antioxidant found in some skin creams and serums. Foods: popcorn, bamboo, whole-grain rye bread, whole-grain oat flakes, sweet corn (cooked) Ferulic acid (FA) is a hydroxycinnamic acid abundant in plant cell walls (notably cereals/whole grains) with strong antioxidant and cytoprotective activity. Mechanistically, FA is frequently described as inducing Nrf2/HO-1 antioxidant programs and suppressing NF-κB-linked inflammation, with additional model-dependent anticancer effects (cell-cycle arrest, apoptosis, reduced invasion). Oral exposure is variable because FA is rapidly metabolized (often as conjugates) and bioaccessibility depends on the food matrix. -Ferulic acid found in dietary strand fractions, especially its free form, has important functions for protecting the human health. -AChE inhibitor (AD) -Cooking results in an increase in free ferulic acid quantity and in a reduction in bound ferulic acid quantity. Bamboo shoots 243.6 mg/100g Sugar-beet pulp 800 mg/100g Popcorn 313 mg/100g Wheat bran 500–1500mg/100g Whole wheat flour 100–300mg/100g
Pathway / Target Modulation by FA / Direction Aβ aggregation ↓ Inhibits fibril formation and destabilizes existing Aβ fibrils BACE‑1 & APP ↓ Reduces BACE-1 and APP expression; ↑ MMP‑2/‑9 expression promoting Aβ clearance Tau hyperphosphorylation Implicitly ↓ through modulation of Ca²⁺/CDK5/GSK3β pathways Ca²⁺ ↓ FA lowers STEP levels via chelation of Ca²⁺, suppressing PP2B → restores synaptic plasticity (AChE / BChE) ↓ Inhibition of AChE (FA IC₅₀~15 µM, derivatives IC₅₀ down to 0.006 µM); also BChE (MAO‑A/B) ↓ Inhibits MAO‑B (derivatives IC₅₀ ~0.3–0.7 µM), reducing ROS ROS ↓ Scavenges ROS, enhances antioxidant enzymes (e.g., catalase), ↓ MDA (COX‑2, 5‑LOX, NLRP3) ↓ Derivatives inhibit COX‑2/5‑LOX; derivative 13a ↓ NLRP3 inflammasome Iron/Cu²⁺ chelation ↓ Metal-induced Aβ aggregation via chelation by FA and derivatives Autophagy & Aβ clearance ↗ Suggested promotion of autophagy mechanisms targeting Aβ
Time-Scale Flag (TSF): P / R / G
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| Also known as HSPA5 Enhanced expression of Hsp70 is associated with tumorigenesis for breast cancer, endometrial cancer, gastric cancer, and acute leukemia; with poor prognoses. -These adenosine triphosphatases unfold misfolded or denatured proteins and can keep these proteins in an unfolded, folding-competent state. They also protect nascently translating proteins, promote the cellular or organellar transport of proteins, reduce proteotoxic protein aggregates and serve general housekeeping roles in maintaining protein homeostasis. -HSP70 family of proteins can be thought of as a potent buffering system for cellular stress, either from extrinsic (physiological, viral and environmental) or intrinsic (replicative or oncogenic) stimuli. As such, this family serves a critical survival function in the cell. Not surprisingly, cancer cells rely heavily on this buffering system for survival. The overwhelming majority of human tumors overexpress HSP70 family members, and expression of these proteins is typically a marker for poor prognosis. -HSP70 helps cancer cells survive under stressful conditions, such as hypoxia or nutrient deprivation, by preventing protein misfolding and aggregation. This allows cancer cells to maintain their proliferative capacity. -Tumor Progression: Elevated levels of HSP70 have been associated with tumor progression and metastasis. |
| 3712- | FA, | Ferulic Acid: A Hope for Alzheimer’s Disease Therapy from Plants |
| - | Review, | AD, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:77 Target#:148 State#:% Dir#:2
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