APC Cancer Research Results

APC, adenomatous polyposis coli: Click to Expand ⟱
Source: CGL-Driver Genes
Type: TSG
The APC protein is a negative regulator that controls beta-catenin concentrations and interacts with E-cadherin, which are involved in cell adhesion. Mutations in the APC gene may result in colorectal cancer and desmoid tumors. The Apc protein is known to interact with several other proteins involved in signal transduction pathways, which regulate cell growth and differentiation.The Apc gene plays a key role in maintaining the integrity of the intestinal epithelium. It functions as a tumor suppressor by inhibiting the abnormal growth of cells and promoting their differentiation. Additionally, this gene helps regulate cell adhesion and migration, ensuring the proper development and function of organs and tissues.The Apc gene acts as a tumor suppressor by regulating the Wnt signaling pathway, which is essential for cell proliferation, differentiation, and self-renewal.
The loss of APC function can lead to dysregulation of the Wnt signaling pathway, contributing to tumorigenesis in various tissues.
Scientific Papers found: Click to Expand⟱
6341- Eug,    A Metabolomic Investigation of Eugenol on Colorectal Cancer Cell Line HT-29 by Modifying the Expression of APC, p53, and KRAS Genes
- NA, Colon, HT29
*antiOx↑, Eugenol demonstrates both antioxidant and prooxidant properties and modulates the expression of genes implicated in cell growth, apoptosis, and angiogenesis in various cancers, including prostate, colon, liver, and ovarian cancers which prevents canc
ROS↑,
tumCV↓, Decreased cell viability was seen to be directly related to concentration- and time-dependent IC50 values (concentration leading to 50% survival)
P53↑, eugenol increased the expression of p53 tumor suppressor gene by 3.2-fold and increased APC expression by 2.5-fold and decreased KRAS oncogene gene by 0.3-fold compared to the control group.
APC↑,
KRAS↓,
FAO↓, Eugenol also showed its anticancer effect in MCF10A-ras breast cancer cells by affecting energy metabolism pathways including reducing fatty acid oxidation and glycolysis cycle and increasing oxidative stress by lowering the regulation of the c-Myc/P
Glycolysis↓,

1013- Lyco,    Lycopene induces apoptosis by inhibiting nuclear translocation of β-catenin in gastric cancer cells
- in-vitro, GC, AGS
Apoptosis↑,
DNAdam↑,
Bax:Bcl2↑,
ROS↓, AGS cells. The results showed that lycopene reduces the levels of ROS
β-catenin/ZEB1↓,
p‑GSK‐3β↓,
APC↑,
β-TRCP↑,
cMyc↓,
cycD1/CCND1↓,


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↓, 1,   ROS↑, 1,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,   FAO↓, 1,   Glycolysis↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   Bax:Bcl2↑, 1,   β-TRCP↑, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   P53↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑GSK‐3β↓, 1,  

Migration ⓘ

APC↑, 2,   KRAS↓, 1,   β-catenin/ZEB1↓, 1,  

Clinical Biomarkers ⓘ

KRAS↓, 1,  
Total Targets: 17

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,  
Total Targets: 1

Scientific Paper Hit Count for: APC, adenomatous polyposis coli
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:12  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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