AntiThr Cancer Research Results
AntiThr, antithrombotic: Click to Expand ⟱
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An antithrombotic agent is a drug that reduces the formation of blood clots.
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Scientific Papers found: Click to Expand⟱
*Wound Healing↑, Antimicrobial effect of AgNPs allows effective use in wound healing and dentistry
*AntiThr↑, AgNPs possess antithrombotic activity useful to treat cardiovascular diseases.
*AntiAg↑, Their anti-platelet effects can be attributed to their ability to prevent or inhibit platelets from adhering to each other.
eff↑, AgNPs makes them excellent agents for photothermal therapy in the treatment of tumours and cancers.
*AntiAg↑, Potentially, materials exhibiting antiplatelet activity may be applied in devices that prevent arterial thrombotic events like ischemic stroke, coronary heart disease, and ischemic gangrene.
*AntiThr↑,
*Dose↝, All four types of AgNPs were spherical in shape with the primary size close to 10 nm
*AntiThr↑, However, advent of biogenic silver nanoparticles with anticoagulant and thrombolytic potentials has opened up a window of opportunity to address most of the shortcomings of the chemical synthesized anticoagulants.
eff↑, Ajoene (4,5,9-trithiadodeca-1,6,11-triene-9-oxide) is a garlic-derived compound produced most efficiently from pure allicin and has the advantage of a greater chemical stability than allicin.
AntiThr↑, ajoene have demonstrated its best-known anti-thrombosis, anti-microbial and cholesterol lowering activities.
Bacteria↓,
LDH↓,
TumCP↓, Ajoene was shown to inhibit proliferation and induce apoptosis of several human leukaemia CD34-negative cells including HL-60, U937, HEL and OCIM-1
TumCCA↑, Studies have shown the anti-proliferation activity of ajoene to be associated with a block in the G2/M phase of cell cycle in human myeloid leukaemia cells.
Bcl-2↓, The apoptosis inducing activity of ajoene is via the mitochondria-dependent caspase cascade through a significant reduction of the anti-apoptotic bcl-2 that results in release of cytochrome c and the activation of caspase-3.
Cyt‑c↑,
Casp3↑,
Dose↝, Cinnamaldehyde (CA), an active compound derived from the natural plant cinnamon, has garnered attention in pharmacological research due to its diverse therapeutic applications.
TumCP↓, CA and its derivatives have antitumor effects, which encompass inhibiting cell proliferation, arresting the cell cycle, inducing apoptosis, limiting cell migration and invasion, and suppressing angiogenesis.
TumCCA↑,
Apoptosis↑,
TumCMig↓,
TumCI↓,
angioG↓,
*Inflam↓, including anti-inflammatory (3), antioxidant (4), antiviral (5), anti-bacterial (6), antithrombic (7), hypoglycemic (8), hepatoprotective (9), anti-diabetic (10), neuroprotective (11) and anticancer effects
*antiOx↑,
*Bacteria↓,
*AntiThr↑,
*hepatoP↑,
*AntiDiabetic↑,
*neuroP↑,
AntiCan↑,
ChemoSen↑, can enhance the effectiveness of anticancer drugs and ensure patient safety.
*BioAv↝, the bioavailability of intravenous administration of CA was superior to that of oral administration
*BioAv↑, A into CA solid lipid nanoparticles, which increased the oral bioavailability of CA by >1.69 times.
eff↑, Especially when combined with hyperthermia therapy at 42°C and 43°C, CA could inhibit cell proliferation
CDK1↓, CB403 (Fig. 1) is a cinnamaldehyde derivative that inhibits the activity of cyclin-dependent kinases (CDKs), particularly CDK1, CDK2 and CDK4, thereby halting cell cycle progression.
CDK2↓,
CDK4↓,
cJun↓, 2-hydroxycinnamaldehyde (HCA; Fig. 1) inhibits the growth of SW620 colon cancer cells by reducing the expression of c-Jun and c-Fos, inhibiting the DNA binding activity of activator protein 1, and inducing cell apoptosis
cFos↓,
Apoptosis↑,
PI3K↓, CA can induce apoptosis in colon cancer cells by inhibiting the PI3K/Akt signaling pathway
Akt↓,
E-cadherin↑, CA upregulates the expression of E-cadherin while downregulating the expression of matrix metalloproteinase-2 (MMP2) and MMP9
MMP2↓,
MMP9↓,
TOP1↓, increases the sensitivity of CRC cells to 5-FU by reducing the expression of thymidylate synthase, ERCC1, DNA topoisomerase 1 and BRCA1
BRCA1↓,
ROS↑, CA was also able to induce apoptosis in cancer cells by increasing intracellular ROS levels
BAX↑, A induces cell apoptosis by upregulating Bax expression, and downregulating Bcl-2 and X-linked inhibitor of apoptosis (XIAP) expression
Bcl-2↓,
XIAP↓,
MMP↓, CA can also induce apoptosis in leukemia K562 cells by reducing the mitochondrial transmembrane potential via mitochondrial-mediated pathways
STAT3↓, figure 2
mTOR↓,
NF-kB↓, ↓NF-κB
eff↑, CA-Cu-PDA was able to release copper ions and CA in tumor cells, and weakened the antioxidant system by binding to glutathione (GSH), which in turn produced additional ROS, thereby inducing enhanced oxidative stress effects
toxicity↓, Consistent with these findings, another study has demonstrated that CA does not exhibit genotoxic or carcinogenic effects on the body
cardioP↑, CA has demonstrated a capacity to alleviate cardiotoxicity induced by DOX
*cardioP↑, describes the cardioprotective potential of dandelion products and preparations.
*Dose↝, Dandelion is a rich source of phenolic acids (chicoric acid, chlorogenic acid), flavonoids (luteolin derivatives, quercetin), and terpenes (sesquiterpene lactones).
*Dose↝, It is also a strong source of vitamins (A, C, E, K, and B) and minerals (calcium, sodium, magnesium, iron, copper, silicon, zinc, manganese)
*toxicity∅, Although dandelion is mainly known for its medicinal properties, it has for many years been successfully used worldwide in the food industry as an entirely non-toxic and edible plant
*toxicity↓, dose should not exceed 4 g or 12 g per day for the aerial parts of the plant or 1 g or 3 g per day for the root. The roots, leaves, and flowers may be eaten raw or cooked
*BP↓, Dandelion leaves are also believed to have a positive effect on the cardiovascular system due to their high potassium content (397 mg potassium/100 g): increased potassium intake with food (about 3500 mg/day for an adult) has been found to lower BP
*Inflam↓, sesquiterpene lactones, which have been found to have anti-inflammatory and antibacterial effects, as well as triterpenes or phytosterols, which possess anti-atherosclerotic properties
*Bacteria↓,
*Imm↑, roots are also rich in inulin, which has a probiotic, hypoglycemic, and immune-boosting effect
*lipid-P↓, extract was found to elevate total antioxidant capacity and decrease lipid peroxidation, a marker of oxidative stress, in the heart, liver, kidney, and brain, among others.
*AST↓, ; treatment was found to improve the lipid profile and aspartate aminotransferase (AST) and alanine aminotransferase (ALT) concentrations in obese mice.
*ALAT↓,
*AntiAg↑, extracts E2 and E3 and fractions A, B, and C significantly inhibited ADP-activated platelet adhesion to fibrinogen, while flavonoid fractions A to C inhibited thrombin-activated platelet adhesion at both tested doses (10 and 50 μg/mL)
*ROS↓, (1) the inhibition of reactive oxygen species (ROS) production;
*AntiThr↑, antithrombotic effects.
*AntiThr↑, Rutin@AgNPs is a potential anticoagulant for antithrombotic therapy
*AntiAg↑, rutin effectively targets the PDI and inhibits its activity, thus the platelet accumulation and fibrin generation can be blocked
*antiOx↑, rutin is a kind of flavonoid, which contains antioxidation and anti-inflammatory activities.
*Inflam↓,
Showing Research Papers: 1 to 7 of 7
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 7
Pathway results for Effect on Cancer / Diseased Cells:
Redox & Oxidative Stress ⓘ
ROS↑, 1,
Mitochondria & Bioenergetics ⓘ
MMP↓, 1, XIAP↓, 1,
Core Metabolism/Glycolysis ⓘ
LDH↓, 1,
Cell Death ⓘ
Akt↓, 1, Apoptosis↑, 2, BAX↑, 1, Bcl-2↓, 2, Casp3↑, 1, Cyt‑c↑, 1,
Transcription & Epigenetics ⓘ
AntiThr↑, 1, cJun↓, 1,
DNA Damage & Repair ⓘ
BRCA1↓, 1,
Cell Cycle & Senescence ⓘ
CDK1↓, 1, CDK2↓, 1, CDK4↓, 1, TumCCA↑, 2,
Proliferation, Differentiation & Cell State ⓘ
cFos↓, 1, mTOR↓, 1, PI3K↓, 1, STAT3↓, 1, TOP1↓, 1,
Migration ⓘ
E-cadherin↑, 1, MMP2↓, 1, MMP9↓, 1, TumCI↓, 1, TumCMig↓, 1, TumCP↓, 2,
Angiogenesis & Vasculature ⓘ
angioG↓, 1,
Immune & Inflammatory Signaling ⓘ
NF-kB↓, 1,
Drug Metabolism & Resistance ⓘ
ChemoSen↑, 1, Dose↝, 1, eff↑, 4,
Clinical Biomarkers ⓘ
BRCA1↓, 1, LDH↓, 1,
Functional Outcomes ⓘ
AntiCan↑, 1, cardioP↑, 1, toxicity↓, 1,
Infection & Microbiome ⓘ
Bacteria↓, 1,
Total Targets: 39
Pathway results for Effect on Normal Cells:
Redox & Oxidative Stress ⓘ
antiOx↑, 2, lipid-P↓, 1, ROS↓, 1,
Core Metabolism/Glycolysis ⓘ
ALAT↓, 1,
Transcription & Epigenetics ⓘ
AntiThr↑, 6,
Migration ⓘ
AntiAg↑, 4,
Immune & Inflammatory Signaling ⓘ
Imm↑, 1, Inflam↓, 3,
Drug Metabolism & Resistance ⓘ
BioAv↑, 1, BioAv↝, 1, Dose↝, 3,
Clinical Biomarkers ⓘ
ALAT↓, 1, AST↓, 1, BP↓, 1,
Functional Outcomes ⓘ
AntiDiabetic↑, 1, cardioP↑, 1, hepatoP↑, 1, neuroP↑, 1, toxicity↓, 1, toxicity∅, 1, Wound Healing↑, 1,
Infection & Microbiome ⓘ
Bacteria↓, 2,
Total Targets: 22
Scientific Paper Hit Count for: AntiThr, antithrombotic
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
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