AntiArt Cancer Research Results
AntiArt, AntiArthritis: Click to Expand ⟱
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AntiArthritis
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Scientific Papers found: Click to Expand⟱
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Inflam↓, various cancers has been demonstrated and it modulates cell signaling pathways, including inflammation, angiogenesis, apoptosis, autophagy, and the cell cycle.
angioG↓,
Apoptosis↑,
TumAuto↑,
TumCCA↑,
BioAv↓, Despite its promising pharmacological activities, the clinical utility of chrysin remains limited due to its poor bioavailability, low solubility, limited permeability, and rapid metabolism.
Half-Life↓,
BioAv↓, The oral bioavailability of chrysin has been reported to range from 0.003% to 0.02%, with a maximum plasma concentration between 12 and 64 nM
*ROS↓, The study reported that chrysin administration protected the kidneys and liver of rats from oxidative damage induced by chronic ethanol consumption
*hepatoP↑, Hepatoprotective Potential
*RenoP↑, The renal protective effect of chrysin was related to increasing the antioxidant enzyme activities and decreasing the regulation of serum renal toxicity markers.
TET1↑, chrysin meaningfully induced the expression of TET1 in GC cells.
MMP9↓, hrysin might contribute to its anticancer effects by regulating MMP-9 expression.
cMyc↓, Both c-Myc and Ki-67 expressions were found to be suppressed in the tumor tissues treated with chrysin and G1-treated tumor tissues
Ki-67↓,
CBR1↓, chrysin directly interacts with CBR1, inhibiting its enzymatic activity at both the molecular and cellular levels.
ROS↑, This inhibition led to elevated intracellular ROS levels, triggering ROS-dependent autophagy
ChemoSen↑, chrysin enhances pancreatic cancer cell sensitivity to gemcitabine by inducing ferroptosis death, both in vitro and in vivo
Bax:Bcl2↑, chrysin increased the Bax/Bcl-2 expression ratio in ATC cells following treatment
PUMA↑, PUMA and Notch-1 were activated, and Slug was inactivated by chrysin treatment
NOTCH1↑,
*AntiDiabetic↑, Anti-Diabetic Potential
*neuroP↑, Neuroprotective Effects
*GABA↑, treatment of chrysin improves levels of GABA, monoamines, glutamic acid, and their metabolites in three brain regions, while also inhibiting DNA fragmentation markers like 8-HdG as well as BDNF.
*DNAdam↓,
*BDNF↑,
*memory↑, protective effects of chrysin against memory impairments associated with hippocampal neurogenesis
*AGEs↓, figure 6
*Aβ↓,
*cardioP↑, Cardioprotective Effects
*AntiArt↑, Anti-Arthritis Potential
eff↑, combination potential was higher than apigenin or chrysin alone.
eff↑, combination of quercetin enhanced the toxic effects of chrysin on the cell lines
*eff↑, neuroprotective synergistic effects of chrysin and kaempferol revealed therapeutic potential in mitigating cerebral ischemi
RadioS↑, study reported that treatment of MDA-MB-231 cells with chrysin in combination with radiation therapy (RT) caused synergistic antitumor properties.
eff↑, the combination of metformin and chrysin demonstrated pronounced synergistic cytotoxic effects on cancer cells
ChemoSen↑, chrysin was combined with a low dose of cisplatin, the resulting growth inhibition was significantly enhanced.
eff↑, demonstrating greater potency than chrysin or silver nanoparticles alone [198].
*diuretic↑, These properties are diuretic, hepatoprotective, anticolitis, immunoprotective, antiviral, antifungal, antibacterial, antiarthritic, antidiabetic, antiobesity, antioxidant and anticancer effects
*hepatoP↑,
*Imm↑,
*Bacteria↓,
*AntiArt↑,
*AntiDiabetic↑,
*Obesity↓,
*antiOx↓,
*AntiCan↑,
Dose?, The main phytochemicals are: carotenoids; flavonoids (e.g., quercetin, chrysoeriol, luteolin-7-glucoside); phenolic acids (e.g., caffeic acid, chlorogenic acid, chicoric acid); polysaccharides (e.g., inulin); sesquiterpene lactones (e.g., taraxinic a
*Inflam↓, The wide range of eugenol activities includes antimicrobial, anti-inflammatory, analgesic and antioxidant.
*antiOx↑,
*NF-kB↓, Eugenol also has an inhibitory effect on cell proliferation via suppression of NF-Kappa B (NF-kB).
*AntiArt↑, eugenol may have recovery effects on arthritis and can be useful as a beneficial supplement in the treatment of arthritis.
*lipid-P↓, Eugenol has prevented depression by decreasing the lipid peroxidation and stimulating reduced glutathione (GSH).25
*GSH↑,
ROS↑, The cytotoxic effects of eugenol, induction of reactive oxygen species (ROS) production and reduced levels of GSH have been studied in human submandibular cell line.
GSH↓,
ChemoSen↑, The combination of eugenol and gemcitabine resulted in a decrease in cell viability of 84% (eugenol alone) to 47% (combination of eugenol-gemcitabine).
Apoptosis↑, Furthermore, eugenol has been found to induce apoptosis by destruction the mitochondrial membrane potential and production of reactive oxygen species.38
MMP↓,
TumCG↓, Eugenol showed different degrees of cytotoxicity in HL-60 cancer cells and inhibited the cell growth by 50% at a concentration of 23.7 µM.
TumCCA↑, eugenol arrests cells in the S phase of the cell cycle and induces apoptosis by this function.
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*AntiCan↑, (Eug), a volatile phenolic bioactive compound with a formula of C10H12O2, has been reported to have anticancer, antidiabetic, cardio‐ and pulmonary protective roles.
*AntiDiabetic↑,
*cardioP↑, Eugenol has been proven effective in modulating gut microbiota and attenuating adiposity in high‐fat diet‐fed C57BL/6J mice.
*toxicity↝, According to WHO, the safe dose of eugenol is 2.5 mg/kg for consumption
*GutMicro↑,
*neuroP↑, Moreover, it has the ability to improve gut health and prevent neurodegenerative disorders.
*BioAv⇅, Furthermore, multiple carriers like liposomes, glycodendritic polyamine dextran, solid lipid nanoparticles, and corn protein nanoparticles have been reported to deliver eugenol.
*BioAv↝, Eugenol (150 mg) in gelatin capsules was orally administered in healthy adults and absorbed very quickly, and ~55% is eliminated in urine after being transformed to glucuronic acid or eugenol sulfate conjugate in the liver
*antiOx↑, The studies on eugenol have proved its antioxidant and anti‐inflammatory properties.
*Inflam↑,
*AntiArt↑, aMateen et al. (2019) reported that eugenol alleviated arthritis via attenuating pro‐inflammatory cytokines (TNF‐α, IL‐6, IL‐10).
*TNF-α↓,
*IL6↓,
*IL10↓,
*GSH↑, Eugenol (2.5, 5, 10 mg/kg) improved GSH, GPx, and CAT levels while reducing carrageenan‐induced OS in arthritic rats (Adefegha et al. 2019).
*GPx↑,
*Catalase↑,
*MDA↓, reported reduced MDA and improved SOD, CAT, and TAC levels.
*TAC↑,
TumCMig↓, eugenol subdued cell migration and invasion by suppressing angiogenesis‐related protein expression and modulating JAK2/STAT3 pathways.
TumCI↓,
Akt↑, MDA‐MB‐231, SK‐BR‐3 ↑AKT, FOXO3a, Caspase‐3/9, p21
FOXO3↑,
Casp3↑,
Casp9↑,
P21↑,
angioG↓, Eugenol has been reported to reduce angiogenesis, inhibit invasion, and trigger apoptosis
TumCI↓,
Apoptosis↑,
NF-kB↓, GC via apoptosis induction, metastasis inhibition, downregulation of NF‐κB, and angiogenesis reduction is shown in Figure 3
eff↑, eugenol (153 μM) combined with 5‐fluorouracil proved effective in inhibiting cell growth and division in HeLa cells.
eff↑, eugenol (200–350 μM) with sulforaphane (6.5–8 μM) lowered the expressions of COX‐2, IL‐β, and Bcl‐2 and inhibited cell proliferation
ChemoSen↑, co‐treatment of eugenol and cisplatin reduced cell proliferation and induced apoptosis in G361 melanoma cells via inhibited MMP and proteasome activity,
NA↑, Eugenol proved effective in HL‐60 cell lines by inducing ROS‐mediated apoptosis with a 23.7 IC50 value
Casp3↑, eugenol‐induced apoptosis via ROS production and caspase‐9/3 activation.
Casp9↑,
*AntiDiabetic↑, Chilukoti et al. (2024) verified the antidiabetic activity of eugenol in rats.
*glucose↓, eugenol (400 mg/kg) significantly lowered glucose levels, reduced OS and inflammation, inhibited MDA levels, and improved GSH.
*ROS↓,
*Inflam↓,
*MDA↓,
*GSH↑,
*BioAv↑, Multiple delivery systems, such as liposomes, nanoparticles, nanoemulsions, and hydrogels, enhance its bioavailability, controlled release, and targeted delivery, making eugenol more effective for pharmaceutical and biomedical applications.
Showing Research Papers: 1 to 4 of 4
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4
Pathway results for Effect on Cancer / Diseased Cells:
NA, unassigned ⓘ
CBR1↓, 1, NA↑, 1,
Redox & Oxidative Stress ⓘ
GSH↓, 1, ROS↑, 2,
Mitochondria & Bioenergetics ⓘ
MMP↓, 1,
Core Metabolism/Glycolysis ⓘ
cMyc↓, 1,
Cell Death ⓘ
Akt↑, 1, Apoptosis↑, 3, Bax:Bcl2↑, 1, Casp3↑, 2, Casp9↑, 2, PUMA↑, 1,
Autophagy & Lysosomes ⓘ
TumAuto↑, 1,
Cell Cycle & Senescence ⓘ
P21↑, 1, TumCCA↑, 2,
Proliferation, Differentiation & Cell State ⓘ
FOXO3↑, 1, NOTCH1↑, 1, TumCG↓, 1,
Migration ⓘ
Ki-67↓, 1, MMP9↓, 1, TET1↑, 1, TumCI↓, 2, TumCMig↓, 1,
Angiogenesis & Vasculature ⓘ
angioG↓, 2,
Immune & Inflammatory Signaling ⓘ
Inflam↓, 1, NF-kB↓, 1,
Drug Metabolism & Resistance ⓘ
BioAv↓, 2, ChemoSen↑, 4, Dose?, 1, eff↑, 6, Half-Life↓, 1, RadioS↑, 1,
Clinical Biomarkers ⓘ
Ki-67↓, 1,
Total Targets: 33
Pathway results for Effect on Normal Cells:
NA, unassigned ⓘ
AntiArt↑, 4, diuretic↑, 1,
Redox & Oxidative Stress ⓘ
antiOx↓, 1, antiOx↑, 2, Catalase↑, 1, GPx↑, 1, GSH↑, 3, lipid-P↓, 1, MDA↓, 2, ROS↓, 2, TAC↑, 1,
Core Metabolism/Glycolysis ⓘ
glucose↓, 1,
DNA Damage & Repair ⓘ
DNAdam↓, 1,
Immune & Inflammatory Signaling ⓘ
IL10↓, 1, IL6↓, 1, Imm↑, 1, Inflam↓, 2, Inflam↑, 1, NF-kB↓, 1, TNF-α↓, 1,
Synaptic & Neurotransmission ⓘ
BDNF↑, 1, GABA↑, 1,
Protein Aggregation ⓘ
AGEs↓, 1, Aβ↓, 1,
Drug Metabolism & Resistance ⓘ
BioAv↑, 1, BioAv⇅, 1, BioAv↝, 1, eff↑, 1,
Clinical Biomarkers ⓘ
GutMicro↑, 1, IL6↓, 1,
Functional Outcomes ⓘ
AntiCan↑, 2, AntiDiabetic↑, 4, cardioP↑, 2, hepatoP↑, 2, memory↑, 1, neuroP↑, 2, Obesity↓, 1, RenoP↑, 1, toxicity↝, 1,
Infection & Microbiome ⓘ
Bacteria↓, 1,
Total Targets: 40
Scientific Paper Hit Count for: AntiArt, AntiArthritis
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
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