diuretic Cancer Research Results

diuretic, diuretic: Click to Expand ⟱
Source:
Type:

diuretic is a substance that makes the body produce and excrete more urine.

| Use                                   | Why diuretics help                                     |
| ------------------------------------- | ------------------------------------------------------ |
| High blood pressure                   | Lower fluid volume, reducing pressure in blood vessels |
| Edema / swelling                      | Remove excess fluid from tissues                       |
| Heart failure                         | Reduce fluid overload                                  |
| Kidney or liver-related fluid buildup | Help manage retained fluid                             |


Scientific Papers found: Click to Expand⟱
6348- DRE,    New prospects in oncotherapy: bioactive compounds from Taraxacum officinale
- Review, Var, NA
Dose↝, Key bioactive compounds, such as taraxasterol, chlorogenic acid, chicoric acid, and taraxinic acid, have been identified as promising agents capable of inhibiting tumor cell proliferation and modulating oncogenic pathways.
TumCP↓,
toxicity↓, Given its multi-target biological activity and low toxicity, Taraxacum officinale holds significant potential for integration into oncotherapy as an adjuvant treatment.
*AntiDiabetic↑, reported to exhibit a broad spectrum of pharmacological effects, including antidiabetic, antioxidant, hepatoprotective, diuretic, anti-inflammatory, neuroprotective, antidepressant, antimicrobial, and immunostimulant properties
*antiOx↑,
*hepatoP↑,
*diuretic↑,
*Inflam↓,
*neuroP↑,
*Imm↑,
eff↑, Innovative formulations such as silver nanoparticles synthesized using aqueous leaf extracts (TOL-AgNPs) demonstrated enhanced cytotoxicity, achieving 95% inhibition of HepG2 cell proliferation at 200 μg/mL
Apoptosis↑, Figure 1
tumCV↓,
selectivity↑,
TumCMig↓, taraxasterol inhibits papillary thyroid cancer cell migration and prevents epithelial-mesenchymal transition (EMT) induced by TGF-β by decreasing the expression of matrix metalloproteinases MMP-2 and MMP-9 and blocking the Wnt/β-catenin signaling pa
EMT↓,
MMP2↓,
MMP9↓,
Wnt↓,
β-catenin/ZEB1↓,
PI3K↓, regulation of key signaling pathways such as PI3K/Akt, JNK, and ERK1/2.
Akt↓,
JNK↓,
ERK↓,

6366- DRE,    A comprehensive review of the benefits of Taraxacum officinale on human health
- Review, Var, NA
*diuretic↑, These properties are diuretic, hepatoprotective, anticolitis, immunoprotective, antiviral, antifungal, antibacterial, antiarthritic, antidiabetic, antiobesity, antioxidant and anticancer effects
*hepatoP↑,
*Imm↑,
*Bacteria↓,
*AntiArt↑,
*AntiDiabetic↑,
*Obesity↓,
*antiOx↓,
*AntiCan↑,
Dose?, The main phytochemicals are: carotenoids; flavonoids (e.g., quercetin, chrysoeriol, luteolin-7-glucoside); phenolic acids (e.g., caffeic acid, chlorogenic acid, chicoric acid); polysaccharides (e.g., inulin); sesquiterpene lactones (e.g., taraxinic a

6365- DRE,    AN OVERVIEW OF THERAPEUTIC POTENTIALS OF TARAXACUM OFFICINALE (DANDELION): A TRADITIONALLY VALUABLE HERB WITH A REACH HISTORICAL BACKGROUND
- Review, Var, NA
*Inflam↓, including anti-inflammatory, anti-tumor, immunostimulatory, anti-microbial, anti-viral, anti-oxidant, anti-diabetic, geno-protective, diuretic and kidney-protective, hepato-protective, neuro-protective
*AntiTum↑,
*Imm↑,
*antiOx↑,
*AntiDiabetic↑,
*diuretic↑,
*RenoP↑,
*hepatoP↑,
*neuroP↑,
AntiTum↑, In 1981, for the first time, it was shown that the hot water extract of dandelion possessed anti-tumor activity
TNF-α↑, It induces apoptotic cell death by raising the production of tumor necrosis factor (TNF)-α and interleukin (IL)-1α
IL1β↑,
Apoptosis↑, The TNF-α and IL-1α are two potent inducers of cancer cell apoptosis
MMP2↓, dampening the activities of matrix metallopro- teinases (MMPs) such as MMP-2 and MMP-9
MMP9↑,
eff↑, Combination treatment with TRAIL targeting and dandelion resulted in TRAIL-induced apoptosis mediated through inhibition of the MKK7-TIPRL interaction and subsequent ac- tivation of MKK7-JNK phosphorylation.
Diff↑, The differentiation-inducing effects of dandelion on the human leukemia cell line (HL60) and a B16 mouse melanoma-derived sub-clone with high differentiation capability (B16 2F2) were investigated
*ROS↓, Both cell viability and ROS assays confirmed that extract effectively attenuated glutamate-induced cytotoxicity and ROS generation.
*HO-1↑, Moreover, extract increased the expression of HO-1 and promoted the nuclear translocation of nuclear factor erythroid 2-relat- ed factor-2 (Nrf2).
*NRF2↑,
*lipid-P↓, andelion can improve lipid metabolism and is advantageous in preventing diabetic complica- tions from lipid peroxidation and free radicals in diabetic rats124


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 2,   JNK↓, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

Diff↑, 1,   EMT↓, 1,   ERK↓, 1,   PI3K↓, 1,   Wnt↓, 1,  

Migration ⓘ

MMP2↓, 2,   MMP9↓, 1,   MMP9↑, 1,   TumCMig↓, 1,   TumCP↓, 1,   β-catenin/ZEB1↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL1β↑, 1,   TNF-α↑, 1,  

Drug Metabolism & Resistance ⓘ

Dose?, 1,   Dose↝, 1,   eff↑, 2,   selectivity↑, 1,  

Functional Outcomes ⓘ

AntiTum↑, 1,   toxicity↓, 1,  
Total Targets: 23

Pathway results for Effect on Normal Cells:


NA, unassigned ⓘ

AntiArt↑, 1,   diuretic↑, 3,  

Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 2,   HO-1↑, 1,   lipid-P↓, 1,   NRF2↑, 1,   ROS↓, 1,  

Immune & Inflammatory Signaling ⓘ

Imm↑, 3,   Inflam↓, 2,  

Functional Outcomes ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 3,   AntiTum↑, 1,   hepatoP↑, 3,   neuroP↑, 2,   Obesity↓, 1,   RenoP↑, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 18

Scientific Paper Hit Count for: diuretic, diuretic
3 Dandelion Root
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1480  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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