PSEN1/PS1 Cancer Research Results

PSEN1/PS1, Presenilin-1: Click to Expand ⟱
Source:
Type:

PSEN1 - Presenilin-1

Abbreviation: PSEN1, PS1

Type: Intramembrane aspartyl protease / catalytic subunit of the γ-secretase complex

Function: PSEN1 is the principal catalytic component of the γ-secretase complex, which performs intramembrane proteolysis of numerous substrates including amyloid precursor protein (APP) and NOTCH receptors. APP cleavage by PSEN1-containing γ-secretase generates amyloid-β peptides including Aβ40 and Aβ42. PSEN1 also regulates cellular signaling, membrane-protein processing, calcium homeostasis, and neuronal function.

Cancer: ↕ Context-dependent. PSEN1-dependent γ-secretase activity can promote oncogenic signaling through cleavage and activation of NOTCH receptors and other substrates. γ-Secretase inhibition can suppress NOTCH-driven proliferation, survival, stemness, and tumor progression in selected cancers, although PSEN1 function varies substantially according to tumor type and substrate context.

Alzheimer's Disease: ↕ Pathogenic alteration of PSEN1 function is a major cause of autosomal-dominant early-onset Alzheimer's disease. Disease-causing PSEN1 mutations alter γ-secretase processivity and commonly increase the relative production of longer, aggregation-prone Aβ species, particularly the Aβ42/Aβ40 ratio. Many pathogenic mutations reduce overall γ-secretase cleavage efficiency, so Alzheimer's disease is better characterized by abnormal PSEN1 function than by a simple increase or decrease in PSEN1 expression.
Scientific Papers found: Click to Expand⟱
8145- LF,    Neuroprotective Effects of Lactoferrin in Alzheimer's and Parkinson's Diseases: A Narrative Review
- Review, AD, NA - Review, Park, NA
*AntiBio↑, Recent advancements in lactoferrin research have uncovered that lactoferrin does function not only as an antimicrobial protein but also as an immunomodulatory, anticancer, and neuroprotective agent.
*Imm↑,
*AntiCan↑,
*neuroP↑,
*BBB↑, Lactoferrin has been shown to cross the blood−brain barrier (BBB)
*APOE4↓, mainly via three mechanisms: (i) inhibiting apolipoprotein 4 (APOE4), (ii) promoting nonamyloidogenic pathway, and (iii) suppressing oxidative stress, inflammation, and apoptosis.
*ROS↓,
*Inflam↓,
*Apoptosis↓,
*Learn↑, In the APP/PS1 transgenic mouse model of AD, Guo et al.95 showed that lactoferrin treatment improved spatial learning and decreased amyloid plaques in the hippocampus and cortex.
*memory↑,
*ADAM10↑, by upregulating enzymatic activities of ADAM10 and PS1 to promote the nonamyloidogenic cleavage of APP.
*PSEN1/PS1↑,
*cl‑APP↑,
*BACE/β-secretase↓, In this study, lactoferrin also increased sAPPα and decreased sAPPβ and CTFβ expressions, likely via the downregulation of BACE1 activities
*cognitive↑, In aged mice, lactoferrin treatment has been demonstrated to attenuate cognitive decline and hippocampal cell loss, as well as lower the markers of oxidative stress (e.g., reactive oxygen species; ROS and malondialdehyde; MDA
*MDA↓,
*IL6↓, and inflammation (e.g., interleukin 6; IL-6 and TNF-α) in the hippocampus.
*TNF-α↓,
*neuroP↑, ntioxidation and anti-inflammation to be involved in the neuroprotective effects of lactoferrin in APP/PS1 transgenic mouse model of AD.
*Dose↝, A pilot randomized controlled trial showed that lactoferrin capsules (250 mg/day of apo-Lf daily for three months) improved cognitive symptoms and biomarkers related to oxidative stres
*IronCh↑, Rousseau et al.71 also showed that the iron-binding capacity of lactoferrin could be neuroprotective but only in the context of iron-induced oxidative stress
*SOD↑, lactoferrin also exhibited antioxidative (reduced ROS levels and increased SOD expression)
*BioAv↝, Most in vivo studies involving AD and PD administered lactoferrin are conducted via intragastric gavage, intranasal instillation, or intraperitoneal injection


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,   APOE4↓, 1,   Learn↑, 1,   PSEN1/PS1↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

MDA↓, 1,   ROS↓, 1,   SOD↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,  

Migration(tgid=13) ⓘ

cl‑APP↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL6↓, 1,   Imm↑, 1,   Inflam↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

ADAM10↑, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↝, 1,   Dose↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   cognitive↑, 1,   memory↑, 1,   neuroP↑, 2,  
Total Targets: 24

Scientific Paper Hit Count for: PSEN1/PS1, Presenilin-1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1650  State#:%  Dir#:2
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