IRes Cancer Research Results

IRes, Insulin Resistance: Click to Expand ⟱
Source:
Type:

Insulin Resistance - Reduced Cellular Responsiveness to Insulin

Type: Metabolic phenotype / insulin-signaling dysfunction

Function: Insulin resistance is a state in which target tissues respond inadequately to insulin, resulting in impaired glucose uptake and altered metabolic signaling. It is commonly associated with compensatory hyperinsulinemia, dysregulated PI3K/AKT signaling, inflammation, oxidative stress, mitochondrial dysfunction, and altered lipid metabolism.

Cancer: ↑ Increased insulin resistance and associated hyperinsulinemia can promote a pro-tumorigenic metabolic environment through enhanced insulin/IGF signaling, inflammation, altered lipid metabolism, and increased growth-factor availability. The strength of this association varies by cancer type.

Alzheimer's Disease: ↑ Increased peripheral and brain insulin resistance is associated with impaired neuronal glucose utilization, synaptic dysfunction, neuroinflammation, oxidative stress, abnormal tau phosphorylation, and altered amyloid processing. Improved insulin sensitivity is generally considered favorable.
Scientific Papers found: Click to Expand⟱
7829- FA,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA
*BioAv↑, Ferulic acid (4-hydroxy-3-methoxycinnamic acid) is abundant in some cereal grains and shows relatively higher absorption in the gastrointestinal mucosa compared to other phenolic acids
*cognitive↓, oral administration of ferulic acid (200 mg/d plus 40 mg of Angelica archangelica extract) daily for 48 weeks improved the mild cognitive impairment in populations aged 65−85 years old.
*Dose↝, ferulic acid (200 mg/d plus 40 mg of Angelica archangelica extract) daily for 48 weeks
*neuroP↑, ferulic acid might possess great neuroprotective potential in the neurodegenerative diseases.
*Aβ↓, ferulic acid reduced Aβ plaque deposits via inhibiting β-secretase (BACE1) activity and cleavage, as well as enhancing α-secretase (ADAM10) activity and cleavage in APP/PS1 mice
*BACE/β-secretase↓,
*ADAM10↑,
*Ac-histone H3↑, ferulic acid improved the cholinergic deficits as indicated by the increased ACh level in the cortex of Aβ1−42 -injected (i.c.v.) mice after ferulic acid treatmen
*BloodF↑, rerulic acid improved the cerebral blood flow (CBF) and insulin resistance, which helped to reduce the progression of AD pathology
*IRes↑,
*memory↑, while ferulic acid treatment (20 mg/kg, p.o.) improved the capillary hypofunction and reduced the memory deficits of APP/PS1 mice.
*Dose↝, Notably, the effective doses of ferulic acid in rodents were 5.3−30 mg/kg when administered for more than 4 weeks, which could be achieved through daily intake of appropriate amount of mung bean

8056- KAE,    Kaempferol: advances in biosynthesis, molecular mechanisms, and therapeutic applications
- Review, Var, NA - Review, Diabetic, NA
*antiOx↑, The principal mechanism of kaempferol is rooted in its potent antioxidant capacity, acting through both direct radical scavenging and the upregulation of the cytoprotective Nrf2 pathway.
*ROS↓,
*NRF2↑,
*Inflam↓, This redox modulation is intricately linked to its anti-inflammatory effects, which are mediated by the suppression of key signaling cascades including NF-κB, MAPKs, and STATs.
*NF-kB↓,
*MAPK↓,
*STAT↓,
*AntiDiabetic↑, kaempferol demonstrates significant antidiabetic activity by activating AMPK and enhancing insulin sensitivity.
*AMPK↑,
*IRes↑,
Apoptosis↑, Its anticancer properties are equally notable, involving the induction of apoptosis, cell cycle arrest, and inhibition of metastasis through the disruption of pathways such as PI3K/AKT and Wnt/β-catenin.
TumCCA↑,
TumMeta↓,
PI3K↓,
Akt↓,
Wnt↓,
β-catenin/ZEB1↓,
*AntiBio↑, Furthermore, it exhibits antimicrobial effects and hepatoprotective actions by modulating SIRT1/AMPK signaling.
*hepatoP↑,
*SIRT1↝,
*BioAv↓, therapeutic translation is severely hampered by its poor aqueous solubility and extensive first-pass metabolism, which critically limit oral bioavailability.


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PI3K↓, 1,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

TumMeta↓, 1,   β-catenin/ZEB1↓, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,   IRes↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   NRF2↑, 1,   ROS↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

Ac-histone H3↑, 1,   AMPK↑, 1,   SIRT1↝, 1,  

Cell Death(tgid=5) ⓘ

MAPK↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

STAT↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,   NF-kB↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

ADAM10↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   BACE/β-secretase↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,   Dose↝, 2,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1,   cognitive↓, 1,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 1,  
Total Targets: 24

Scientific Paper Hit Count for: IRes, Insulin Resistance
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1674  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

Home Page