antiAll Cancer Research Results

antiAll, antiallergic: Click to Expand ⟱
Source:
Type:

Antiallergic Activity - Suppression of Allergic Responses

Type: Therapeutic effect / immune phenotype / functional outcome

Function: Antiallergic activity refers to suppression of allergic sensitization, mast-cell or basophil activation, IgE-mediated signaling, eosinophilic inflammation, histamine and leukotriene release, airway inflammation, or other manifestations of hypersensitivity.

Asthma: ↓ Allergic response is favorable. Increased antiallergic activity corresponds to reduced IgE/FcεRI signaling, mast-cell degranulation, eosinophil recruitment, type-2 cytokine signaling, mucus production, bronchoconstriction, and airway hyperresponsiveness.

Favorable Direction: ↑ Antiallergic activity = beneficial.
Scientific Papers found: Click to Expand⟱
8105- KAE,    Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review
- Review, Var, NA
Apoptosis↑, It induces apoptosis (HeLa cervical cancer cells), decreases cell viability (G2/M phase), downregulates phosphoinositide 3-kinase (PI3K)/AKT
tumCV↓,
TumCCA↑,
PI3K↓,
Akt↓,
EMT↓, suppresses protein expression of epithelial-mesenchymal transition (EMT)-related markers including N-cadherin, E-cadherin, Slug, and Snail, and metastasis-related markers such as matrix metallopeptidase 2 (MMP-2).
N-cadherin↓,
E-cadherin↓, nhibition of N‐cadherin, E‐cadherin, Slug, Snail, and MMP‐2, 9, and cathepsin B, D
Slug?,
Snail?,
MMP2↓,
MMP9↓,
CTSB↓,
CTSD↓,
Casp3↑, Activation of caspase signals such as caspase‐3, ‐8, and ‐9
Casp8↑,
Casp9↑,
TIMP2↓, Down‐regulation of phosphorylated TIMP2, AKT, and MMP2 levels
Akt↓,
TumCD↑, Induction of cell apoptotic cell death, intracellular free calcium elevation, and mitochondrial membrane potential disruption.
i-Ca+2↑,
MMP↓,
*ROS↓, Enhances the concentrations of superoxide dismutase, catalase, glutathione peroxidase, and glutathione‐S‐transferase.
*SOD↑,
*Catalase↑,
*GPx↑,
*GSTs↑,
*AST↓, Lowers aspartate aminotransferase, alanine aminotransferase, malondialdehyde (MDA).
*ALAT↓,
*MDA↓,
*CYP2E1↓, Decreases activity of hepatic microsomal enzyme cytochrome 2E1 (CYP2E1) expression
*NRF2↑, Increases mRNA and protein expression of Nrf2‐regulated genes
*AGEs↓, Suppresses advanced glycation end products (AGEs)‐ receptor.
*IL6↓, Reduces levels of IL‐6, TNF‐α, and NF‐κB.
*TNF-α↓,
*NF-kB↓,
*Casp3↓, Lowers expressions of Caspase‐3 and Bax,
*BAX↓,
*antiAll↑, Antiallergic Inhibits COX2‐mediated production of prostaglandin D2 and prostaglandin F2α.
*COX2/PTGS2↓,
*PGE2↓,
*RUNX2↑, Increases expression of the osteoblast‐activated factors RUNX‐2, BMP‐2, osterix, collagen I, and SQSTM1/p62
*BMP2↑,
*COL1↑,
*p62↑,
*FASN↓, Reduces expressions of lipin1, FASN, LPAATθ (lysophosphatidic acid acyltransferase), SREBP‐1C (fatty acid synthetic proteins), and DGAT1 (triglyceride synthetic enzymes).
*DGAT1↓,
FOXP3↑, kaempferol significantly enhanced the inhibitory effect of proliferation, increased the FOXP3 expression level,
DNAdam↑, s induction of DNA damage, enhancement DNA condensation
ROS↑, anti‐cancer property is mainly defined by ROS accumulation due to catalase inhibition as depicted in Figure 2
Catalase↓,
*ROS↓, (A/R)‐induced injury of cardiomyocytes by increasing cell viability, lowering LDH release, reducing A/R‐induced ROS generation, loss of Δψm, and release of cytochrome c from mitochondria into cytosol.
*MMP↑,
*Cyt‑c↓,

8154- lamb,    Anti-allergic effect of lambertianic acid from Thuja orientalis in mouse bone marrow-derived mast cells
- in-vitro, Nor, NA
*IL6↓, lambertianic acid inhibited the production of interleukin-6 (IL-6), PGD(2) and LTC(4), the expression of COX-2 and the degranulation of β-hexosaminidase in the PMA plus calcimycin-induced BMMCs.
*PGD2↓,
*LTC4↓,
*COX2/PTGS2↓,
*β-HEX↓, figure5
*antiAll↑, Therefore, lambertianic acid was deemed to possess potentially anti-allergic activity.

8150- lamb,    Reactive oxygen species dependent phosphorylation of the liver kinase B1/AMP activated protein kinase/ acetyl-CoA carboxylase signaling is critically involved in apoptotic effect of lambertianic acid in hepatocellular carcinoma cells
- in-vitro, HCC, HepG2 - in-vitro, HCC, SK-HEP-1
lipidLev↓, Though lambertianic acid (LA) is reported to have hypolipidemic activity in liver
TumCCA↑, LA increased cytotoxicity, sub-G1 population and Annexin V/PI positive cells in two HCC cells
cl‑Casp3↑, LA cleaved caspase-3 and poly(ADP-ribose) polymerase (PARP), activated phosphorylation of liver kinase B1 (LKB1)/AMP activated protein kinase (AMPK)/ acetyl-CoA carboxylase (ACC) pathway
cl‑PARP↑,
AMPK↑,
Akt↓, also suppressed antiapoptotic proteins such as phosphorylation of Akt/ mammalian target of rapamycin (mTOR) and the expression of B cell lymphoma-2 (Bcl-2)/ B-cell lymphoma-extra large (Bcl-xL) and cyclooxygenase-2 (COX-2) in two HCC cells.
mTOR↓,
Bcl-2↓,
Bcl-xL↓,
COX2/PTGS2↓,
ROS↑, LA generated reactive oxygen species (ROS) in HepG2 cells
eff↓, AMPK inhibitor compound C or ROS inhibitor N-acetyl-L-cysteine (NAC) blocked the apoptotic ability of LA to cleave PARP or increase sub G1 population in HepG2 cells.
p‑STK11/LKB1↑, Overall, these findings suggest that ROS dependent phosphorylation of LKB1/AMPK/ACC signaling is critically involved in LA induced apoptosis in HCCs.
p‑ACC↑,
*Obesity↓, labmertianic acid (LA) is known to have anti-obesity [40], stress-protective [41], anti-allergic [42] and neurotropic
*Stress↓,
*antiAll↑,
tumCV↓, LA significantly suppressed the viability of HepG2, SK-Hep1 and Hep3B cells in a concentration dependent fashion, but not Chang normal hepatocyte cells.
selectivity↑,
TumCP↓, LA significantly inhibited proliferation of two HCC cells in a concentration and time dependent manner

8148- lamb,    Anti-Cancer Effect of Lambertianic Acid by Inhibiting the AR in LNCaP Cells
- in-vitro, Pca, LNCaP
*antiAll↑, Lambertianic acid (LA) is known to have anti-allergic and antibacterial effects
*Bacteria↓,
AR↓, LA decreased not only AR protein levels, but also cellular and secretory levels of PSA.
PSA↓,
TumCCA↑, LA suppressed cell proliferation by inducing G1 arrest, downregulating CDK4/6 and cyclin D1 and activating p53 and its downstream molecules, p21 and p27.
CDK4↓,
CDK6↓,
cycD1/CCND1↓,
P53↑,
P21↑,
p27/CDKN1B↓,
Apoptosis↑, LA induced apoptosis and the expression of related proteins, including cleaved caspase-9 and -3, c-PARP and BAX, and inhibited BCl-2.
cl‑Casp9↑,
cl‑Casp3↑,
cl‑PARP↑,
BAX↑,
Bcl-2↓,
Dose↝, LA decreased the number of LNCaP cells concentration and time dependently (IC50 109 μM).

8156- lamb,    A review on chemistry, source and therapeutic potential of lambertianic acid
- Review, Var, NA
*Obesity↓, potential health benefits in attenuating obesity, allergies and different cancers including breast, liver, lung and prostate cancer.
*AntiCan↑,
*AMPK↑, rats with high fat diet (HFD)-induced obesity by activating adenosine monophosphate activated protein kinase (AMPK)
*β-HEX↓, it was also observed that LA can suppress the release of β-hexosaminidase in a concentration-independent manner in BMMC
NA↑, anti-allergic activity
TumCCA↑, LA-treated MDA-MB-231 cells revealed that LA induces G2/ M phase arrest
AMPK↑, , LA activates AMPK and acetyl-CoA carboxylase (ACC) through phosphorylation and can suppress protein kinase B (AKT) phosphorylation,
ACC↑,
p‑Akt↓,
FOXM1↓, LA actively attenuates the expression of forkhead box protein M1 (FOXM1) and its regulated gene products, including proliferative proteins (Cyclin B1) and anti-apoptotic proteins (X-linked inhibitor of apoptosis protein [XIAP] and B-cell lymphoma 2 [
CycB/CCNB1↓,
XIAP↓,
Bcl-2↓,
p‑STAT3↓, LA suppresses the phosphorylation of STAT3 and NF-κB, the expression of p300 and RelA/ p65 acetylation,
p‑NF-kB↓,
Bcl-xL↓, LA blocks the expression of NF-κB regulated genes, including anti-apoptotic proteins (Bcl-2, Bcl-xL, XIAP and survivin), angiogenic protein vascular endothelial growth factor (VEGF), inflammatory protein COX-2, oncogenic genes cellular myelocytomato
survivin↓,
VEGF↓,
COX2/PTGS2↓,
cMyc↓,
IL6↓, and inflammatory mediators IL-6 and tumour necrosis factor-alpha (TNF-α) in the MCF-7 cells
TNF-α↓,
ROS↑, LA exhibits anticancer effects on hepatocellular carcinoma cells (HCC) through induction of apoptotic pathway by ROS-dependent activation of liver kinase B1 (LKB1)/AMPK/ ACC signalling cascades
STK11/LKB1↑,
cl‑Casp3↑, it induces the cleavage of caspase-3 and PARP along with the suppression of antiapoptotic proteins, Bcl-2 and Bcl-xl.
cl‑PARP↑,
eff↑, LA (20 μM) together with TRAIL (20 ng/ml) shows significant cytocidal effects in TRAIL resistant nonsmall cell lung cancer cell
AR↓, LA exerts anticancer effects by suppressing AR pathway in AR-sensitive prostate cancer cells LNCaP.
TumCP↓, 24 h LA treatment downregulates cell proliferation by reducing several protein levels, including p-53, p-p53, p21, p27, cyclin D1 and cell division kinase 4 (CDK4).
p‑P53↓,
P21↓,
p27/CDKN1B↓,
cycD1/CCND1↓,
CDK4↓,
PSA↓, LA exhibits anticancer properties by inhibiting AR expression and PSA in cellular and secretory levels
STAT3↓, LA induces apoptosis via miRNA-134 mediated inhibition of STAT3 and RelA/p65 acetylation
ac‑p65↓,
*antiAll↑, In conclusion, LA could be utilized in treating allergies, obesity and different cancers.

7954- RT,    Rutin : therapeutic potential and recent advances in drug delivery
- Review, Nor, NA - Review, IBD, NA
*antiOx↑, Rutin is a highly potent molecule due to its strong antioxidant properties
*antiAll↑, antiallergic [21] , anti-inflammatory and vasoactive [22] , antitumor [23] , antibacterial, antiviral, and antiprotozoal properties
*Inflam↓,
*AntiTum↑,
*Bacteria↓,
*AntiViral↑,
*BioAv↓, The major disadvantage associated with this molecule is poor solubility in aqueous media, being the reason for its poor bioavailability.
*AntiArt↑, Antiarthritic activity
*PLA2↓, rutin inhibited PLA2 activity, the initial enzyme in arachidonic acid cascade, from human synovial fluid
*chemoP↑, Rutin pretreatment prevented deteriorative effects induced by cisplatin through a protective mechanism that involved reduction of increased oxidative stress as well as caspase-3, TNF-a and NF-kB protein expression levels.
*ROS↓,
*Casp3↓,
*TNF-α↓,
*NF-kB↓,
*cardioP↑, Recent studies have shown the protective effect of rutin in various cardiovascular disorders such as hypertension, hyperlipidemia and myocardial infarction
*Stroke↓, The protective effects of rutin in myocardial infarction could be due to free radical scavenging activity, improving of multienzyme activities such as Na + /K + ATPase and Mg 2+ -ATPase and Ca 2+ -ATPase
*TG/TAG↓, Rutin significantly lowered levels of cholesterol, TGs, free fatty acids (FFAs), LDL-C, and VLDL-C in serum and increased the level of HDL-C in serum in ISO-treated rats (
*FFA/NEFA↓,
*LDL↓,
*HDL↑,
*AntiDiabetic↑, Rutin acts as an antidiabetic agent in several ways by enhancing the release of insulin from islets of langerhans,
*MPO↓, Rutin has shown to be effective in treatment of IBD due to its anti-inflammatory effects, which involve reduction in myeloperoxidase activity and inhibition of TNF-a-induced NF-kB activation in human colon cells and expression of IL-1b
*NF-kB↓,
*BioAv↓, The oral bioavailability of pure rutin is around 20%
*BioAv↝, Common approaches used to enhance bioavailability of rutin are particle diminution to the submicron range and by complexation of rutin with cyclodextrins and various metals.


Showing Research Papers: 1 to 6 of 6

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1,   ROS↑, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↑, 1,   p‑ACC↑, 1,   AMPK↑, 2,   cMyc↓, 1,   lipidLev↓, 1,   STK11/LKB1↑, 1,   p‑STK11/LKB1↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 3,   p‑Akt↓, 1,   Apoptosis↑, 2,   BAX↑, 1,   Bcl-2↓, 3,   Bcl-xL↓, 2,   Casp3↑, 1,   cl‑Casp3↑, 3,   Casp8↑, 1,   Casp9↑, 1,   cl‑Casp9↑, 1,   p27/CDKN1B↓, 2,   survivin↓, 1,   TumCD↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   P53↑, 1,   p‑P53↓, 1,   cl‑PARP↑, 3,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4↓, 2,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 2,   P21↓, 1,   P21↑, 1,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CTSB↓, 1,   CTSD↓, 1,   EMT↓, 1,   FOXM1↓, 1,   mTOR↓, 1,   PI3K↓, 1,   STAT3↓, 1,   p‑STAT3↓, 1,  

Migration(tgid=13) ⓘ

i-Ca+2↑, 1,   E-cadherin↓, 1,   MMP2↓, 1,   MMP9↓, 1,   N-cadherin↓, 1,   Slug?, 1,   Snail?, 1,   TIMP2↓, 1,   TumCP↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   FOXP3↑, 1,   IL6↓, 1,   p‑NF-kB↓, 1,   ac‑p65↓, 1,   PSA↓, 2,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2,   CDK6↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,   eff↓, 1,   eff↑, 1,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 2,   FOXM1↓, 1,   IL6↓, 1,   PSA↓, 2,  
Total Targets: 72

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

antiAll↑, 6,   AntiArt↑, 1,   FFA/NEFA↓, 1,   LTC4↓, 1,   PLA2↓, 1,   Stress↓, 1,   Stroke↓, 1,   β-HEX↓, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↑, 1,   CYP2E1↓, 1,   GPx↑, 1,   GSTs↑, 1,   HDL↑, 1,   MDA↓, 1,   MPO↓, 1,   NRF2↑, 1,   ROS↓, 3,   SOD↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   AMPK↑, 1,   DGAT1↓, 1,   FASN↓, 1,   LDL↓, 1,  

Cell Death(tgid=5) ⓘ

BAX↓, 1,   BMP2↑, 1,   Casp3↓, 2,   Cyt‑c↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

p62↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

RUNX2↑, 1,  

Migration(tgid=13) ⓘ

COL1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   IL6↓, 2,   Inflam↓, 1,   NF-kB↓, 3,   PGD2↓, 1,   PGE2↓, 1,   TNF-α↓, 2,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   IL6↓, 2,   TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 1,   AntiTum↑, 1,   cardioP↑, 1,   chemoP↑, 1,   Obesity↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   Bacteria↓, 2,  
Total Targets: 54

Scientific Paper Hit Count for: antiAll, antiallergic
4 lambertianic acid
1 Kaempferol
1 Rutin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

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