RELN Cancer Research Results

RELN, Reelin: Click to Expand ⟱
Source:
Type:

RELN - Reelin

Abbreviation: RELN, Reelin

Type: Secreted extracellular-matrix glycoprotein / neuronal signaling protein

Function: Reelin binds ApoER2 and VLDLR and activates DAB1-dependent signaling. It regulates neuronal migration during development and, in the adult brain, supports synaptic plasticity, long-term potentiation, NMDA receptor function, cytoskeletal regulation, and memory.

Alzheimer's Disease: ↕ Dysregulated / functionally impaired. Reelin signaling is disturbed in Alzheimer's disease. Reduced Reelin occurs in vulnerable brain regions and during earlier disease stages, while increased Reelin can occur later as a compensatory response despite impaired downstream signaling. Effective Reelin signaling can reduce pathological tau phosphorylation, influence APP processing, and support synaptic NMDA receptor function.

Favorable Direction in Alzheimer's Disease: ↑ Effective RELN-Reelin signaling is generally favorable, even though measured Reelin protein abundance alone does not necessarily indicate effective pathway activity.
Scientific Papers found: Click to Expand⟱
8084- KAE,    Kaempferol treatment ameliorates memory impairments in STZ‑induced neurodegeneration by acting on reelin signaling
- in-vivo, AD, NA
*Learn↑, *memory↑, *GAD1/GAD67↑, *RELN↑, *p‑NMDAR↑, *neuroP↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

GAD1/GAD67↑, 1,   Learn↑, 1,   p‑NMDAR↑, 1,   RELN↑, 1,  

Functional Outcomes(tgid=23) ⓘ

memory↑, 1,   neuroP↑, 1,  
Total Targets: 6

Scientific Paper Hit Count for: RELN, Reelin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1760  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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