EDEM Cancer Research Results

EDEM, ER Degradation-Enhancing α-Mannosidase-Like Proteins: Click to Expand ⟱
Source:
Type:

EDEM Family - ER Degradation-Enhancing α-Mannosidase-Like Proteins

Members: EDEM1, EDEM2, EDEM3

Type: ER-associated degradation regulators / glycoprotein quality-control proteins / GH47 family

Function: EDEM proteins participate in endoplasmic-reticulum-associated degradation (ERAD) by recognizing and processing terminally misfolded glycoproteins and promoting their removal from the ER for proteasomal degradation. EDEM proteins are induced during ER stress and form part of the unfolded protein response-associated protein quality-control system.

Cancer: ↕ Context-dependent. Increased EDEM/ERAD activity can help tumor cells survive chronic proteotoxic, metabolic, and hypoxic stress by clearing misfolded proteins, while excessive or disrupted ERAD can contribute to ER stress and cell death. Cancer effects therefore depend on tumor type and ER-stress context.
Scientific Papers found: Click to Expand⟱
8187- LGE,    Modulation of oxidative stress and subsequent induction of apoptosis and endoplasmic reticulum stress allows citral to decrease cancer cell proliferation
- in-vitro, BC, 4T1 - in-vitro, Ovarian, OVCAR-3 - in-vitro, Ovarian, SKOV3
TumCP↓, Here, we show that citral inhibits proliferation of multiple human cancer cell lines.
TumCCA↑, In p53 expressing ECC-1 and OVCAR-3 but not in p53-deficient SKOV-3 cells, citral induces G1/S cell cycle arrest and apoptosis
Apoptosis↑,
cl‑Casp3↑, increased cleaved caspase3 and Bax and decreased Bcl-2.
BAX↑,
Bcl-2↓,
ER Stress↑, In SKOV-3 cells, citral induces the ER stress markers CHOP, GADD45, EDEM, ATF4, Hsp90, ATG5, and phospho-eIF2α.
CHOP/DDIT3↑,
GADD45A↑,
EDEM↑,
ATF4↑,
HSP90↑,
ATG5↑,
eIF2α↑,
ROS↑, Citral increases intracellular oxygen radicals and this leads to activation of p53
P53↑,
eff↓, Pretreatment with N-acetylcysteine NAC decreases phosphorylation of p53 in citral-treated ECC-1 and OVCAR-3.


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

EDEM↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   cl‑Casp3↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   eIF2α↑, 1,   ER Stress↑, 1,   HSP90↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

GADD45A↑, 1,   P53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

ATF4↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↓, 1,  
Total Targets: 17

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: EDEM, ER Degradation-Enhancing α-Mannosidase-Like Proteins
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1775  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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