miR-27a-3p Cancer Research Results

miR-27a-3p, miR-27a-3p: Click to Expand ⟱
Source:
Type: oncogenic miRNA
miR-27a-3p is often found to be upregulated. It can promote tumor growth and metastasis by targeting and downregulating tumor suppressor genes.
Scientific Papers found: Click to Expand⟱
8113- LA,    Analyzing of colorectal cancer related genes and microRNAs expression profiles in response to probiotics Lactobacillus acidophilus and Saccharomyces cerevisiae in colon cancer cell lines
- in-vitro, CRC, HT-29 - in-vitro, CRC, SW480
BAX↑, upregulation in the BAX, CASP3, and CASP9 and down regulation BCl-2, MMP2, and MMP9 genes
Casp3↑,
Casp9↑,
Bcl-2↓,
MMP2↓,
MMP9↓,
miR-34a↑, Also, a comparison of microRNA expression profiles indicated an increase of miR 34, 135, 25, 16, 195, 27, 98, let7 and a decrease of miR 9, 106b, 17, 21, 155, 221.
miR-25-5p↑,
miR-195↑,
miR-27a-3p↑,
Let-7↑,
miR-106b↓,
miR-17↓,
miR-21↓,
miR-155↓,
miR-221↓,
TumPF↓, The findings of this study indicate that probiotics can effectively suppress the proliferation of colorectal cancer cells and even reverse their development.


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

miR-106b↓, 1,   miR-195↑, 1,  

Cell Death(tgid=5) ⓘ

BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp9↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

miR-25-5p↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

miR-21↓, 1,   miR-27a-3p↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Let-7↑, 1,   miR-34a↑, 1,  

Migration(tgid=13) ⓘ

miR-155↓, 1,   miR-221↓, 1,   MMP2↓, 1,   MMP9↓, 1,   TumPF↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

miR-17↓, 1,  
Total Targets: 17

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: miR-27a-3p, miR-27a-3p
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:192  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

Home Page