AXIN1 Cancer Research Results

AXIN1, Axis inhibition protein 1: Click to Expand ⟱
Source: CGL-Driver Genes
Type: TSG
AXIN1 is a tumor suppressor and a crucial negative regulator of the Wnt/β-catenin signaling pathway. Abnormal expression of AXIN1 protein has been shown to be associated with various tumors, including CRC.
Axin1 Protein expression was decreased remarkably in tumor specimens when compared to normal tissues. Alterations of Axin1 including AXIN1 gene mutations and decreased Axin1 expression have been reported in several types of solid tumors.
Scientific Papers found: Click to Expand⟱
1103- CBD,    Cannabidiol inhibits invasion and metastasis in colorectal cancer cells by reversing epithelial-mesenchymal transition through the Wnt/β-catenin signaling pathway
- vitro+vivo, NA, NA
Apoptosis↑,
TumCP↓,
TumCMig↓,
TumMeta↓,
EMT↓,
E-cadherin↑,
N-cadherin↓,
Snail↓,
Vim↓,
Hif1a↓,
Wnt/(β-catenin)↓,
AXIN1↑,
TumVol↓, orthotopic xenograft tumors
TumW↓,

8009- itraC,    Itraconazole exerts its anti-melanoma effect by suppressing Hedgehog, Wnt, and PI3K/mTOR signaling pathways
- vitro+vivo, Melanoma, SK-MEL-28 - vitro+vivo, Melanoma, A375
OS↑, we find that itraconazole can inhibit melanoma growth and extend the survival of melanoma xenograft mice, compared to non-itraconazole-treated mice.
TumCP↓, itraconazole can significantly inhibit cell proliferation, as demonstrated by Ki-67 staining in itraconazole-treated tumor tissues
Ki-67↓,
TumCP↓, itraconazole inhibits the proliferation and colony formation of both SK-MEL-28 and A375 human melanoma cells.
Gli1↓, itraconazole significantly down-regulates Gli-1, Gli-2, Wnt3A, β-catenin and cyclin D1, while it up-regulates Gli-3 and Axin-1, indicating potent inhibitory effects of itraconazole on Hedgehog (Hh) and Wnt signaling pathways.
GLI2↓,
Wnt↓,
β-catenin/ZEB1↓,
cycD1/CCND1↓,
AXIN1↑,
GLI3↑,
AXIN1↑,
HH↓,
PI3K↓, itraconazole significantly suppresses the PI3K/mTOR signaling pathway
Akt↓,
*toxicity↓, mice under high doses of itraconazole (75 mg/kg or 100mg/kg) experienced some liver function impairments, as average levels of ALT and ALKP were slightly higher in these mice compared to mice with lower or no doses of itraconazole even though no stat


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

AXIN1↑, 3,   EMT↓, 1,   Gli1↓, 1,   HH↓, 1,   PI3K↓, 1,   Wnt↓, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

E-cadherin↑, 1,   GLI2↓, 1,   GLI3↑, 1,   Ki-67↓, 1,   N-cadherin↓, 1,   Snail↓, 1,   TumCMig↓, 1,   TumCP↓, 3,   TumMeta↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

Ki-67↓, 1,  

Functional Outcomes(tgid=23) ⓘ

OS↑, 1,   TumVol↓, 1,   TumW↓, 1,  
Total Targets: 26

Pathway results for Effect on Normal Cells:


Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: AXIN1, Axis inhibition protein 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:23  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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