GLI3 Cancer Research Results

GLI3, GLI3: Click to Expand ⟱
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GLI1, GLI2, and GLI3 are key downstream effectors of the Hh signaling pathway, acting as nuclear transcription factors that bind to promoters to regulate target gene expression. Highly expressed genes in human gliomas.
Scientific Papers found: Click to Expand⟱
8009- itraC,    Itraconazole exerts its anti-melanoma effect by suppressing Hedgehog, Wnt, and PI3K/mTOR signaling pathways
- vitro+vivo, Melanoma, SK-MEL-28 - vitro+vivo, Melanoma, A375
OS↑, we find that itraconazole can inhibit melanoma growth and extend the survival of melanoma xenograft mice, compared to non-itraconazole-treated mice.
TumCP↓, itraconazole can significantly inhibit cell proliferation, as demonstrated by Ki-67 staining in itraconazole-treated tumor tissues
Ki-67↓,
TumCP↓, itraconazole inhibits the proliferation and colony formation of both SK-MEL-28 and A375 human melanoma cells.
Gli1↓, itraconazole significantly down-regulates Gli-1, Gli-2, Wnt3A, β-catenin and cyclin D1, while it up-regulates Gli-3 and Axin-1, indicating potent inhibitory effects of itraconazole on Hedgehog (Hh) and Wnt signaling pathways.
GLI2↓,
Wnt↓,
β-catenin/ZEB1↓,
cycD1/CCND1↓,
AXIN1↑,
GLI3↑,
AXIN1↑,
HH↓,
PI3K↓, itraconazole significantly suppresses the PI3K/mTOR signaling pathway
Akt↓,
*toxicity↓, mice under high doses of itraconazole (75 mg/kg or 100mg/kg) experienced some liver function impairments, as average levels of ALT and ALKP were slightly higher in these mice compared to mice with lower or no doses of itraconazole even though no stat


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death(tgid=5) ⓘ

Akt↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

AXIN1↑, 2,   Gli1↓, 1,   HH↓, 1,   PI3K↓, 1,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

GLI2↓, 1,   GLI3↑, 1,   Ki-67↓, 1,   TumCP↓, 2,   β-catenin/ZEB1↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

Ki-67↓, 1,  

Functional Outcomes(tgid=23) ⓘ

OS↑, 1,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: GLI3, GLI3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

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