n-MYC Cancer Research Results

n-MYC, n-MYC Oncogene: Click to Expand ⟱

Source:

Type: Oncogene

The MYC proto-oncogenes are among the most commonly activated proteins in human cancer. N-myc is primarily implicated in high-grade neuroendocrine tumors (neuroblastoma and small-cell carcinomas) and those arising from the neural system (neuroblastoma, medulloblastoma, and glioblastoma).

It is a potent developmental regulator that controls proliferation, metabolism, ribosome biogenesis, and cell-cycle progression during embryogenesis—especially in neural crest–derived tissues.

Overexpression is generally associated with a more aggressive clinical course and lower survival rates.

Scientific Papers found: Click to Expand⟱

3245-

EGCG,

(−)-Epigallocatechin-3-gallate protects PC12 cells against corticosterone-induced neurotoxicity via the hedgehog signaling pathway

in-vitro,

Nor,

PC12

*neuroP↑, *Shh↑, *Gli1↑, *n-MYC↑, *Dose↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

Proliferation, Differentiation & Cell State ⓘ

Gli1↑, 1, n-MYC↑, 1, Shh↑, 1,

Drug Metabolism & Resistance ⓘ

Dose↝, 1,

Functional Outcomes ⓘ

neuroP↑, 1,
Total Targets: 5

Scientific Paper Hit Count for: n-MYC, n-MYC Oncogene

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells