RUNX2 Cancer Research Results
RUNX2, Runt-related transcription factor 2: Click to Expand ⟱
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RUNX2 (Runt-related transcription factor 2) is a transcription factor that plays a crucial role in the regulation of bone development and osteoblast differentiation.
RUNX2 is overexpressed in: breast, prostate, lung, osteosarcoma.
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Scientific Papers found: Click to Expand⟱
Apoptosis↑, It induces apoptosis (HeLa cervical cancer cells), decreases cell viability (G2/M phase), downregulates phosphoinositide 3-kinase (PI3K)/AKT
tumCV↓,
TumCCA↑,
PI3K↓,
Akt↓,
EMT↓, suppresses protein expression of epithelial-mesenchymal transition (EMT)-related markers including N-cadherin, E-cadherin, Slug, and Snail, and metastasis-related markers such as matrix metallopeptidase 2 (MMP-2).
N-cadherin↓,
E-cadherin↓, nhibition of N‐cadherin, E‐cadherin, Slug, Snail, and MMP‐2, 9, and cathepsin B, D
Slug?,
Snail?,
MMP2↓,
MMP9↓,
CTSB↓,
CTSD↓,
Casp3↑, Activation of caspase signals such as caspase‐3, ‐8, and ‐9
Casp8↑,
Casp9↑,
TIMP2↓, Down‐regulation of phosphorylated TIMP2, AKT, and MMP2 levels
Akt↓,
TumCD↑, Induction of cell apoptotic cell death, intracellular free calcium elevation, and mitochondrial membrane potential disruption.
i-Ca+2↑,
MMP↓,
*ROS↓, Enhances the concentrations of superoxide dismutase, catalase, glutathione peroxidase, and glutathione‐S‐transferase.
*SOD↑,
*Catalase↑,
*GPx↑,
*GSTs↑,
*AST↓, Lowers aspartate aminotransferase, alanine aminotransferase, malondialdehyde (MDA).
*ALAT↓,
*MDA↓,
*CYP2E1↓, Decreases activity of hepatic microsomal enzyme cytochrome 2E1 (CYP2E1) expression
*NRF2↑, Increases mRNA and protein expression of Nrf2‐regulated genes
*AGEs↓, Suppresses advanced glycation end products (AGEs)‐ receptor.
*IL6↓, Reduces levels of IL‐6, TNF‐α, and NF‐κB.
*TNF-α↓,
*NF-kB↓,
*Casp3↓, Lowers expressions of Caspase‐3 and Bax,
*BAX↓,
*antiAll↑, Antiallergic Inhibits COX2‐mediated production of prostaglandin D2 and prostaglandin F2α.
*COX2/PTGS2↓,
*PGE2↓,
*RUNX2↑, Increases expression of the osteoblast‐activated factors RUNX‐2, BMP‐2, osterix, collagen I, and SQSTM1/p62
*BMP2↑,
*COL1↑,
*p62↑,
*FASN↓, Reduces expressions of lipin1, FASN, LPAATθ (lysophosphatidic acid acyltransferase), SREBP‐1C (fatty acid synthetic proteins), and DGAT1 (triglyceride synthetic enzymes).
*DGAT1↓,
FOXP3↑, kaempferol significantly enhanced the inhibitory effect of proliferation, increased the FOXP3 expression level,
DNAdam↑, s induction of DNA damage, enhancement DNA condensation
ROS↑, anti‐cancer property is mainly defined by ROS accumulation due to catalase inhibition as depicted in Figure 2
Catalase↓,
*ROS↓, (A/R)‐induced injury of cardiomyocytes by increasing cell viability, lowering LDH release, reducing A/R‐induced ROS generation, loss of Δψm, and release of cytochrome c from mitochondria into cytosol.
*MMP↑,
*Cyt‑c↓,
*miR-34b-5p↓, expression of miR-34b-5p decreased under SEMF stimulation,
*ALP↑, significant upregulation in the relative expression levels of osteogenic markers (ALP, RUNX2, BMP2, OCN, and OPN)
*RUNX2↑,
*BMP2↑,
*OCN↑,
*OPN↑,
*β-catenin/ZEB1↑, protein expression levels of osteogenic makers, including Active-β-catenin, RUNX2, and ALP, were elevated upon SEMFs exposure at 0.4 mT, 0.7 mT, and 1 mT
*STAC2↑, subsequently increasing STAC2 level.
*Diff↑, electromagnetic fields promote the osteogenic differentiation
*BMD↑, low-frequency SEMFs promote osteogenesis
Showing Research Papers: 1 to 2 of 2
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2
Pathway results for Effect on Cancer / Diseased Cells:
Redox & Oxidative Stress(tgid=1) ⓘ
Catalase↓, 1, ROS↑, 1,
Mitochondria & Bioenergetics(tgid=3) ⓘ
MMP↓, 1,
Cell Death(tgid=5) ⓘ
Akt↓, 2, Apoptosis↑, 1, Casp3↑, 1, Casp8↑, 1, Casp9↑, 1, TumCD↑, 1,
Transcription & Epigenetics(tgid=7) ⓘ
tumCV↓, 1,
DNA Damage & Repair(tgid=10) ⓘ
DNAdam↑, 1,
Cell Cycle & Senescence(tgid=11) ⓘ
TumCCA↑, 1,
Proliferation, Differentiation & Cell State(tgid=12) ⓘ
CTSB↓, 1, CTSD↓, 1, EMT↓, 1, PI3K↓, 1,
Migration(tgid=13) ⓘ
i-Ca+2↑, 1, E-cadherin↓, 1, MMP2↓, 1, MMP9↓, 1, N-cadherin↓, 1, Slug?, 1, Snail?, 1, TIMP2↓, 1,
Immune & Inflammatory Signaling(tgid=16) ⓘ
FOXP3↑, 1,
Total Targets: 25
Pathway results for Effect on Normal Cells:
NA, unassigned(tgid=0) ⓘ
antiAll↑, 1,
Redox & Oxidative Stress(tgid=1) ⓘ
Catalase↑, 1, CYP2E1↓, 1, GPx↑, 1, GSTs↑, 1, MDA↓, 1, NRF2↑, 1, ROS↓, 2, SOD↑, 1,
Mitochondria & Bioenergetics(tgid=3) ⓘ
MMP↑, 1,
Core Metabolism/Glycolysis(tgid=4) ⓘ
ALAT↓, 1, DGAT1↓, 1, FASN↓, 1,
Cell Death(tgid=5) ⓘ
BAX↓, 1, BMP2↑, 2, Casp3↓, 1, Cyt‑c↓, 1,
Kinase & Signal Transduction(tgid=6) ⓘ
OCN↑, 1,
Autophagy & Lysosomes(tgid=9) ⓘ
p62↑, 1,
Proliferation, Differentiation & Cell State(tgid=12) ⓘ
Diff↑, 1, RUNX2↑, 2,
Migration(tgid=13) ⓘ
COL1↑, 1, OPN↑, 1, STAC2↑, 1, β-catenin/ZEB1↑, 1,
Angiogenesis & Vasculature(tgid=14) ⓘ
miR-34b-5p↓, 1,
Immune & Inflammatory Signaling(tgid=16) ⓘ
COX2/PTGS2↓, 1, IL6↓, 1, NF-kB↓, 1, PGE2↓, 1, TNF-α↓, 1,
Protein Aggregation(tgid=19) ⓘ
AGEs↓, 1,
Clinical Biomarkers(tgid=22) ⓘ
ALAT↓, 1, ALP↑, 1, AST↓, 1, BMD↑, 1, IL6↓, 1,
Total Targets: 37
Scientific Paper Hit Count for: RUNX2, Runt-related transcription factor 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:776 State#:% Dir#:2
wNotes=on sortOrder:rid,rpid
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