Neut Cancer Research Results
Neut, neutrophils: Click to Expand ⟱
| Source: |
| Type: white blood cell |
Neutrophils are a type of white blood cell that plays a crucial role in the immune system. They are involved in the defense against infections and inflammation.
High levels of neutrophils in the tumor microenvironment have been linked to poor prognosis in various types of cancer, including breast, lung, and colon cancer.
Neutropenia is an abnormally low number of circulating neutrophils
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Scientific Papers found: Click to Expand⟱
*toxicity↓, A reduction in systemic toxicity, statistically significant for neutropenia, associated with better results in term of OR rate, ICR, and BR were observed in group B compared with group A.
chemoP↑, ellagic acid as support therapy reduces chemotherapy induced toxicity, in particular neutropenia, in HRCP patients
Neut↑,
PSA↓, In group B, serum PSA concentrations markedly declined (>75%)
Dose↝, After reviewing the literature, a daily dose of 180 mg (60 g/every 8 h) active principle was selected and administered orally before meals with water (200–250 ml) throughout the chemotherapy cycles and during the period between cycles.
AntiArt↑, this species has been traditionally employed for the treatment of toothache, bowel pain, snake bite, skin disorders, seizure, chronic arthritis, and cancer
*Imm↑, The immunostimulant activity of the plant or its preparations is caused by three mechanisms:
*Neut↑, activation of the neutrophils, macrophages, polymorphonuclear leukocytes (PMN), and natural killer (NK) cells.[
*NK cell↑,
*COX1↓, This effect may be attributed to the inhibition of COX‑1 and to a lesser extent COX‑2 by alkamides.
*COX2/PTGS2↓,
*Inflam↓, The Echinacea preparation, interestingly, has reversed the inflammation caused by some bacteria in a culture of epithelial cells by reducing cytokines
TumCG↑, The extract of the flowers and cichoric acid inhibited both the human colon cancer cell lines Caco‑2 and HCT‑116 in a dose dependent manner after 48 h.
*toxicity↓, Generally, animal studies of various preparations of Echinacea species have shown low toxicity.
Risk↓, Studies using animal models have demonstrated that ingestion of bovine lactoferrin (bLF) inhibits carcinogenesis in the colon and other organs of experimental animals
Dose↝, Patients with colorectal polyps ≤5 mm diameter and likely to be adenomas ingested 0, 1.5, or 3.0 g bLF daily for 1 year.
NK cell↑, Trial participants with regressing polyps had increased NK cell activity, increased serum hLF levels (indicating increased neutrophil activity), and increased numbers of CD4+ cells in the polyps.
Neut↑,
CD4+↑,
Imm↑, These findings are consistent with a correlation between higher immune activity and suppression of colorectal polyps.
APG↓,
Dose↝, Test group (15 patients) received oral bLF 250 mg/day beside chemotherapy for three months. Control group (15 patients) received chemotherapy only.
toxicity↓, 3 months after treatment indicates that no significant difference in mean values of serum creatinine, AST, ALT, serum LF, serum GST enzyme, INF-γ, WBCs count, platelet count, CEA, RBCs count, neutrophil count, and Hb level of patients
INF-γ↝, Mean percent of change of main parameters (serum LF, serum GST enzyme, and INF-γ) after than before treatment among the studied patients indicate significant improvement in patients who received oral bLF 3 months
other↑, The results of this trial indicate that oral bLF made a significant increase in serum LF levels of patients in the test group 3 months after treatment compared to patients in the control group (P ≤ 0.05).
*ROS↓, Iron is essential as a catalyst for the production of reactive oxygen species. Therefore, lactoferrin can diminish the harmful influence of reactive oxygen species produced by leukocytes at the sites of inflammation
Imm↑, This result indicates that oral bLF enhances the immune system of colorectal cancer patients.
WBC↑, As a result of this increase in WBCs and neutrophil count patients disease state may be improved, because the body immune system can fight the disease more efficiently compatible with some previous studies
Neut↑,
T-Cell↑, These results support the proposal that oral supplements of bovine lactoferrin may be a useful adjunct toward modulation of immune activity, in particular T-cell activation and antioxidant status
*antiOx↑, The effect of antioxidants such as LF increase intracellular glutathione (GSH) levels in vascular endothelial cells by modulation of the GSH redox
*GSH↑,
*chemoP↑, On the other hand, oral bLF administration decreased chemotherapy related side effects as it enhances both renal and hepatic function tests.
*RenoP↑, Also, LF decreased chemotherapy related side effects by protecting liver and kidney from toxicity and improving their function test values
*hepatoP↑, Oral lactoferrin may increase liver functions and protect it from damage by reactive oxygen species since LF can function as an antioxidant, reducing intracellular levels of ROS
BUN↓, mean serum BUN decreased from 16.23 mg/dL before treatment to 11.43 mg/dL after 3 months of treatment in patients in the test group
creat↓, This decrease in BUN and serum creatinine may be due to the antioxidant effect of LF as mentioned in a former preclinical study on rat model of ferric nitrilotriacetate- (Fe-NTA-) induced renal tubular oxidative injury.
ALAT↓, Also, there was a significant decrease in serum ALT and AST in patients in test group 3 months after treatment compared to patients in the control group
AST↓,
RBC↑, Oral bLF administration enhanced anemia which is a very common chemotherapy related side effect; as results have shown, there were significant increases in RBCs count and serum Hb in patients in test group 3 months after treatment compared to patient
PC↑, There was a significant increase in platelets count in patients in test group after 3 months compared to control group
Mucositis↓, Patients in test group had less severed mucositis than patients in control group after every chemotherapy cycle;
*AntiBio↑, As mentioned before, lactoferrin has protective effects that range from direct antimicrobial activities against a large panel of microorganisms, including bacteria, viruses, fungi, and parasites, to anti-inflammatory and anticancer activities [
*AntiViral↑,
*AntiFungal↑,
*Inflam↓,
*Inf↓, PBA has a previously undiscovered protective role in host mucosal defense during infection
*GutMicro↑, PBA to Taconic mice resulted in the increase of intestinal Lactobacillales and segmented filamentous bacteria (SFB)
*IL17↑, increase of interleukin 17 (IL-17) production by intestinal cells
*Inflam↓, lower levels of inflammation
*ER Stress↓, PBA also plays a role in the reduction of endoplasmic reticulum (ER) stress caused by the unfolded protein response (UPR), thereby suppressing oxidative stress in several animal models
*ROS↓,
*OS↑, PBA was shown to increase the life span of flies, which was associated with both a global increase in histone acetylation and a marked alteration of gene expression
*Bacteria↓, PBA administration was shown to inhibit the growth of Helicobacter pylori and Escherichia coli
*Neut↑, these results indicated that PBA treatment reduces intestinal inflammation, the recruitment of neutrophils to the gut
*toxicity↓, PBA, which has been safely used in children and adults for the past 20 years to treat urea cycle disorders
Showing Research Papers: 1 to 5 of 5
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5
Pathway results for Effect on Cancer / Diseased Cells:
NA, unassigned(tgid=0) ⓘ
AntiArt↑, 1, APG↓, 1, Mucositis↓, 1, PC↑, 1, RBC↑, 1, WBC↑, 1,
Core Metabolism/Glycolysis(tgid=4) ⓘ
ALAT↓, 1, BUN↓, 1,
Transcription & Epigenetics(tgid=7) ⓘ
other↑, 1,
Proliferation, Differentiation & Cell State(tgid=12) ⓘ
TumCG↑, 1,
Immune & Inflammatory Signaling(tgid=16) ⓘ
CD4+↑, 1, Imm↑, 2, INF-γ↝, 1, Neut↑, 3, NK cell↑, 1, PSA↓, 1, T-Cell↑, 1,
Drug Metabolism & Resistance(tgid=21) ⓘ
Dose↝, 3,
Clinical Biomarkers(tgid=22) ⓘ
ALAT↓, 1, AST↓, 1, creat↓, 1, PSA↓, 1,
Functional Outcomes(tgid=23) ⓘ
chemoP↑, 1, Risk↓, 1, toxicity↓, 1,
Total Targets: 25
Pathway results for Effect on Normal Cells:
NA, unassigned(tgid=0) ⓘ
AntiBio↑, 1,
Redox & Oxidative Stress(tgid=1) ⓘ
antiOx↑, 1, GSH↑, 1, ROS↓, 2,
Protein Folding & ER Stress(tgid=8) ⓘ
ER Stress↓, 1,
Immune & Inflammatory Signaling(tgid=16) ⓘ
COX1↓, 1, COX2/PTGS2↓, 1, IL17↑, 1, Imm↑, 1, Inflam↓, 3, Neut↑, 2, NK cell↑, 1,
Clinical Biomarkers(tgid=22) ⓘ
GutMicro↑, 1,
Functional Outcomes(tgid=23) ⓘ
chemoP↑, 1, hepatoP↑, 1, OS↑, 1, RenoP↑, 1, toxicity↓, 3,
Infection & Microbiome(tgid=24) ⓘ
AntiFungal↑, 1, AntiViral↑, 1, Bacteria↓, 1, Inf↓, 1,
Total Targets: 22
Scientific Paper Hit Count for: Neut, neutrophils
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
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