TumW Cancer Research Results
TumW, Tumor Weight: Click to Expand ⟱
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| Type: |
Tumor Weight
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Scientific Papers found: Click to Expand⟱
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in-vitro, |
SCC, |
KYSE150 |
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in-vitro, |
SCC, |
KYSE450 |
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in-vitro, |
CRC, |
HCT116 |
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in-vitro, |
Liver, |
HepG2 |
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in-vitro, |
Cerv, |
HeLa |
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in-vitro, |
Lung, |
A549 |
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ChemoSen⇅, In vivo, high‑dose kaempferol potentiated cisplatin’s antitumor activity, whereas low‑dose kaempferol diminished it.
HSP70/HSPA5↑, Western blot analysis showed that 1–5 μM kaempferol induced a dose-dependent increase in HSP70 protein, while higher concentrations produced no further elevation
Beclin-1/ATG6⇅, we uncover a generalizable dose-dependent molecular switch in which kaempferol differentially modulates the HSP70–Beclin-1 complex to determine the direction of autophagic flux.
Dose↝, Treatment with 2.5 μM kaempferol increased the IC50 values for cisplatin in all cell lines, whereas 20 μM kaempferol significantly reduced IC50 values
TumVol⇅, Low-dose kaempferol attenuated cisplatin’s antitumor efficacy, increasing tumor volume and weight compared with cisplatin alone, whereas high-dose kaempferol further reduced tumor burden
TumW⇅,
Showing Research Papers: 1 to 1 of 1
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1
Pathway results for Effect on Cancer / Diseased Cells:
Protein Folding & ER Stress(tgid=8) ⓘ
HSP70/HSPA5↑, 1,
Autophagy & Lysosomes(tgid=9) ⓘ
Beclin-1/ATG6⇅, 1,
Drug Metabolism & Resistance(tgid=21) ⓘ
ChemoSen⇅, 1, Dose↝, 1,
Functional Outcomes(tgid=23) ⓘ
TumVol⇅, 1, TumW⇅, 1,
Total Targets: 6
Pathway results for Effect on Normal Cells:
Total Targets: 0
Scientific Paper Hit Count for: TumW, Tumor Weight
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:915 State#:% Dir#:3
wNotes=on sortOrder:rid,rpid
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