Black Seed Oil/Nigella sativa / Dose Cancer Research Results

BSO, Black Seed Oil/Nigella sativa: Click to Expand ⟱
Features:

Black Seed Oil - Nigella sativa Seed Oil

*** many database entries are under TQ the main active ingredient *****

Recommended Abbreviation: BSO

Alternative Names: Nigella sativa oil, black cumin seed oil, black caraway oil, kalonji oil

Type: Botanical oil / natural product / seed oil

Source: Oil obtained from the seeds of Nigella sativa L. (Ranunculaceae), commonly by cold pressing or solvent extraction.

Main Active Constituent: Thymoquinone (TQ) is the best-characterized pharmacologically active volatile constituent of black seed oil.

Other Bioactive Constituents: Thymohydroquinone, dithymoquinone and related quinones, p-cymene, carvacrol, thymol, α-thujene and other terpenes, together with a fixed-oil fraction rich in linoleic acid, oleic acid, palmitic acid, and other fatty acids. The relative concentrations vary with cultivar, geographic origin, storage, and extraction method.

Function: Black seed oil exhibits antioxidant, anti-inflammatory, immunomodulatory, metabolic, antimicrobial, and experimental anticancer activities. Its effects arise from thymoquinone together with other volatile compounds and the fatty-acid-rich fixed-oil fraction.

Cancer: Black seed oil and Nigella sativa preparations have demonstrated preclinical anticancer activity, including proliferation ↓, inflammatory signaling ↓, oxidative-stress modulation, apoptosis ↑, and migration/invasion ↓. Thymoquinone accounts for many of the best-characterized anticancer mechanisms, but whole-oil effects should not automatically be attributed solely to TQ.

Alzheimer's Disease: Black seed oil and Nigella sativa preparations have shown experimental neuroprotective effects involving oxidative stress ↓, neuroinflammation ↓, mitochondrial protection, and cholinergic and memory-related pathways. Thymoquinone is likely an important contributor, but whole-oil studies should be kept distinct from isolated TQ studies.

Database Relationship: Parent botanical product linked primarily to Thymoquinone (TQ), with additional links to other identified constituents where separate product records exist.
Dose, Dosage: Click to Expand ⟱
Source:
Type:
Drug dosage vs efficacy, and actual dosage number of research papers.
Scientific Papers found: Click to Expand⟱
8182- BSO,  LEC,    The Protecting Role of Black Seed Oil and Its Nano-Formulation in LPS-Induced Acute Kidney Injury in Mice: Evaluation of Oxidative Stress, Biochemical & Molecular Parameters
- in-vivo, Nor, NA
*Inflam↓, *ROS↓, *RenoP↑, *Dose↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Functional Outcomes(tgid=23) ⓘ

RenoP↑, 1,  
Total Targets: 4

Scientific Paper Hit Count for: Dose, Dosage
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:483  Target#:1114  State#:%  Dir#:4
  wNotes=0  sortOrder:rid,rpid

 

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