TrkB Cancer Research Results

TrkB, Tropomyosin receptor kinase B: Click to Expand ⟱
Source:
Type:
Tropomyosin receptor kinase B (TrkB, encoded by the NTRK2 gene)

• TrkB is a high‐affinity receptor for brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4).

• It has been implicated in promoting cell survival, proliferation, migration, and resistance to apoptosis.

• In several cancer types, increased TrkB expression has been associated with enhanced tumor aggressiveness and metastasis.
Scientific Papers found: Click to Expand⟱
8234- LCA,    Licochalcone A: A Potential Multitarget Drug for Alzheimer’s Disease Treatment
- Review, AD, NA
*neuroP↑, Studies have reported the neuroprotective effects of Lico-A, suggesting its potential as a multitarget compound.
*PTP1B↓, Lico-A acts as a PTP1B inhibitor, enhancing cognitive activity through the BDNF-TrkB pathway and exhibiting inhibitory effects on microglia activation, which enables mitigation of neuroinflammation
*cognitive↑,
*BDNF↑,
*TrkB↝, It not only enhances cognitive activity via the BDNF-TrkB pathway
*cJun↓, Moreover, Lico-A inhibits c-Jun N-terminal kinase 1, a key enzyme involved in tau phosphorylation,
*p‑tau↓,
*AChE↓, Lico-A also acts as an acetylcholinesterase inhibitor, leading to increased levels of the neurotransmitter acetylcholine (Ach) in the brain.
*Ach↑,
*Aβ↓, Lico-A has shown the ability to reduce amyloid plaques, a hallmark of AD, and exhibits antioxidant properties by activating the nuclear factor erythroid 2-related factor 2 (Nrf2)
*antiOx↑,
*NRF2↑,
*AntiViral↑, figure 1
*Obesity↓,
*PI3K↑, The proposed mechanism is through the activation of the PI3K/Akt/mTOR
*Akt↑,
*mTOR↑,
*memory↑, Licochalcone A as an Acetylcholinesterase Inhibitor and Memory Enhancer
*BBB↑, Furthermore, its ability to penetrate the blood–brain barrier (BBB)


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   NRF2↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 1,   cJun↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTOR↑, 1,   PI3K↑, 1,  

Migration(tgid=13) ⓘ

PTP1B↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BDNF↑, 1,   p‑tau↓, 1,   TrkB↝, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 1,   memory↑, 1,   neuroP↑, 1,   Obesity↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,  
Total Targets: 19

Scientific Paper Hit Count for: TrkB, Tropomyosin receptor kinase B
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1254  State#:%  Dir#:4
  wNotes=on  sortOrder:rid,rpid

 

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