COX17 Cancer Research Results

COX17, cytochrome c oxidase copper chaperone COX17: Click to Expand ⟱
Source:
Type:

COX17 = cytochrome c oxidase copper chaperone COX17, it helps deliver copper for mitochondrial complex IV / cytochrome c oxidase, supporting oxidative phosphorylation, mitochondrial fitness, and in some contexts tumor-cell growth. COX17 is more specifically an intracellular mitochondrial copper trafficking / complex IV assembly factor, not a general copper importer like SLC31A1/CTR1.
Usually pro-cancer when overexpressed or required by OXPHOS-dependent tumor cells



Scientific Papers found: Click to Expand⟱
6171- Cu,    Copper in the tumor microenvironment and tumor metastasis
- Review, Var, NA
*angioG↑, Copper (Cu), an essential micronutrient, plays an essential role in several physiological processes, including cell proliferation and angiogenesis;
other↑, Significant Cu accumulation is observed in several tumor tissues.
*ROS↑, excess Cu accumulation in the tissues facilitates reactive oxygen species (ROS) generation, and is closely associated with Wilson’s disease and neurodegeneration.‍(
CTR1↝, Cellular Cu uptake is accomplished through the Cu importer CTR1 (SLC31A1).‍
other↝, overexpression of STEAPs is observed in several types of cancers, including prostate, colon, pancreas, and breast, these observations are consistent with CTR1 being overexpressed in cancer
COX17↝, As tumor cells have a high ATP requirement, COX17 is frequently over­expressed in clinical tumor tissues and tumor cell lines.
ATOX1↝, Due to the pro-tumor activity of Atox-1, it may be a novel biomarker for breast cancer metastasis


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

COX17↝, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,   other↝, 1,  

Migration ⓘ

ATOX1↝, 1,  

Barriers & Transport ⓘ

CTR1↝, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↑, 1,  
Total Targets: 2

Scientific Paper Hit Count for: COX17, cytochrome c oxidase copper chaperone COX17
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1473  State#:%  Dir#:4
  wNotes=on  sortOrder:rid,rpid

 

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