ATOX1 Cancer Research Results

ATOX1, Antioxidant 1 copper chaperone: Click to Expand ⟱

Source:

Type: Biomarker

<span class="wphighlight">ATOX1</span> is a copper chaperone that delivers copper to ATP7A/ATP7B. In cancer, increased <span class="wphighlight">ATOX1</span> is generally pro-cancer because it can support copper-dependent migration, angiogenesis-related signaling, proliferation, and resistance to platinum drugs such as cisplatin. <span class="wphighlight">ATOX1</span> inhibition or knockdown can reduce migration and tumor growth in some models, but effects are context-dependent because <span class="wphighlight">ATOX1</span> is also needed for normal copper homeostasis.<br>
<span class="wphighlight">ATOX1</span> ↑ is usually pro-cancer<br>
<span class="wphighlight">ATOX1</span> has a strong link to cancer-cell migration.<br>
Due to the pro-tumor activity of Atox-1, it may be a novel biomarker for breast cancer metastasis
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Scientific Papers found: Click to Expand⟱

6171-

Cu,

Copper in the tumor microenvironment and tumor metastasis

Review,

Var,

*angioG↑, Copper (Cu), an essential micronutrient, plays an essential role in several physiological processes, including cell proliferation and angiogenesis;
other↑, Significant Cu accumulation is observed in several tumor tissues.
*ROS↑, excess Cu accumulation in the tissues facilitates reactive oxygen species (ROS) generation, and is closely associated with Wilson’s disease and neurodegeneration.‍(
CTR1↝, Cellular Cu uptake is accomplished through the Cu importer CTR1 (SLC31A1).‍
other↝, overexpression of STEAPs is observed in several types of cancers, including prostate, colon, pancreas, and breast, these observations are consistent with CTR1 being overexpressed in cancer
COX17↝, As tumor cells have a high ATP requirement, COX17 is frequently overexpressed in clinical tumor tissues and tumor cell lines.
ATOX1↝, Due to the pro-tumor activity of Atox-1, it may be a novel biomarker for breast cancer metastasis

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Barriers & Transport ⓘ

CTR1↝, 1,
Total Targets: 5

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

ROS↑, 1,

Angiogenesis & Vasculature ⓘ

angioG↑, 1,
Total Targets: 2

Scientific Paper Hit Count for: ATOX1, Antioxidant 1 copper chaperone

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1474  State#:%  Dir#:4
  wNotes=on  sortOrder:rid,rpid

ATOX1 Cancer Research Results

Pathway results for Effect on Cancer / Diseased Cells:

Mitochondria & Bioenergetics ⓘ

Transcription & Epigenetics ⓘ

Migration ⓘ

Barriers & Transport ⓘ

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

Angiogenesis & Vasculature ⓘ

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