FFA/NEFA Cancer Research Results

FFA/NEFA, Free fatty acids — FFA / non-esterified fatty acids, NEFA: Click to Expand ⟱
Source:
Type: Biomarker 
Free fatty acids may be measured in plasma, tumour tissue, culture medium, or intracellular lipid pools. They provide substrates for:

β-oxidation and ATP production;
membrane lipid synthesis;
lipid signalling;
eicosanoid production;
protein acylation.

However, excessive FFAs can cause lipotoxicity, ROS generation, ER stress, lipid peroxidation, or ferroptosis. Therefore, FFA ↑ is not automatically tumour-promoting or beneficial.


Scientific Papers found: Click to Expand⟱
8110- L-Orn,    L-ornithine supplementation attenuates physical fatigue in healthy volunteers by modulating lipid and amino acid metabolism
- Trial, Nor, NA
*Dose↝, 17 healthy volunteers were randomized to L-ornithine (2000 mg/d for 7 days and 6000 mg/d for 1 day as L-ornithine hydrochloride) or placebo for 8 days
*KeyT↝, oral L-ornithine administration promoted lipid metabolism and activated the urea cycle from serum triacylglycerol, ketone bodies, free fatty acids, and blood ammonia level changing.
*FFA/NEFA↝,
*NH3↓,
*fatigue↓, L-ornithine significantly attenuated the subjective feeling of fatigue


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

FFA/NEFA↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

KeyT↝, 1,   NH3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Functional Outcomes(tgid=23) ⓘ

fatigue↓, 1,  
Total Targets: 5

Scientific Paper Hit Count for: FFA/NEFA, Free fatty acids — FFA / non-esterified fatty acids, NEFA
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1551  State#:%  Dir#:4
  wNotes=on  sortOrder:rid,rpid

 

Home Page