miR-339-5p Cancer Research Results

miR-339-5p, MicroRNA-339-5p: Click to Expand ⟱
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miR-339-5p - MicroRNA-339-5p

Abbreviation: miR-339-5p

Type: MicroRNA / post-transcriptional gene-expression regulator

Function: miR-339-5p is a regulatory microRNA that binds complementary sequences within target mRNAs and suppresses their expression through mRNA degradation and/or translational inhibition. Reported targets include MDM2, BACE1, and other genes involved in proliferation, survival, invasion, and signaling.

Cancer: ↓ Frequently reduced in cancer and predominantly functions as a tumor-suppressive microRNA. miR-339-5p can directly inhibit MDM2, thereby enhancing p53 activity, apoptosis, senescence, and growth arrest. Increased miR-339-5p has also been shown to suppress cancer-cell proliferation, migration, invasion, and tumor growth.

Alzheimer's Disease: ↓ Reduced miR-339-5p has been reported in Alzheimer's disease brain tissue. miR-339-5p directly suppresses BACE1 expression; therefore, loss of miR-339-5p can contribute to increased BACE1 activity and increased amyloidogenic APP processing and Aβ production.

Favorable Direction: ↑ Restoration or increased miR-339-5p activity is generally favorable in both cancer and Alzheimer's disease contexts.
Scientific Papers found: Click to Expand⟱
8087- KAE,    Therapeutic Importance of Kaempferol in the Treatment of Cancer through the Modulation of Cell Signalling Pathways
- Review, Var, NA
TumCCA↓, Kmp can regulate various cancer-related processes and activities such as cell cycle, oxidative stress, apoptosis, proliferation, metastasis, and angiogenesis.
ROS↝,
Apoptosis↑,
TumCP↑,
TumMeta↓,
angioG↓,
PI3K↓, down-regulation of signalling pathways such as phosphatidylinositol 3-kinase-protein kinase B (PI3K-PKB), epithelial mesenchymal transition (EMT) markers’ expression such as SNAI1, E-cadherin and N-cadherin and (MMP2) markers
EMT↓,
Snail↓,
E-cadherin↓,
N-cadherin↓,
MMP2↓,
Casp9↑, Kmp also stimulates the activation of caspases such as caspase-9, caspase-7, caspase-3 and poly (ADP-ribose) polymerase (PARP) proteins which involve in initiation and execution of apoptosis
Casp7↑,
PARP↑,
Apoptosis↑,
*ROS↓, hence, inhibiting the reactive oxygen species (ROS) accumulation included in the development of cancer
Hif1a↓, Kmp reduces the level of hypoxia inducible factor (HIF)-1 and inhibits phosphorylation of AKT signalling pathway and it blocks signalling mechanisms which involves in enhanced VEGF secretion
p‑Akt↓,
P53↑, Luo et al. (2011) observed that Kmp prevented phosphorylation of AKT signalling but upregulated the p53 expression and induced apoptosis in ovarian cancerous cells
cMyc↓, figure 5
Glycolysis↓, In a study it was found that by modulating miR-339-5p-hnRNPA1/PTBP1-PKM2 axis, kaempferol inhibits glycolysis and colon cancer growth,
PKM2↓,
miR-339-5p↝,
BioAv↓, Kmp is poorly absorbed with very deprived oral bioavailability, and it is usually metabolized into glucuronide, methyl, or sulphate forms


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

miR-339-5p↝, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

cMyc↓, 1,   Glycolysis↓, 1,   PKM2↓, 1,  

Cell Death(tgid=5) ⓘ

p‑Akt↓, 1,   Apoptosis↑, 2,   Casp7↑, 1,   Casp9↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,   PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,   PI3K↓, 1,  

Migration(tgid=13) ⓘ

E-cadherin↓, 1,   MMP2↓, 1,   N-cadherin↓, 1,   Snail↓, 1,   TumCP↑, 1,   TumMeta↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hif1a↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,  
Total Targets: 23

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: miR-339-5p, MicroRNA-339-5p
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1762  State#:%  Dir#:4
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