Cit/L-Cit Cancer Research Results

Cit/L-Cit, citrulline: Click to Expand ⟱
Source:
Type:

Citrulline - L-Citrulline

Abbreviation: Cit, L-Cit

Type: Non-protein amino acid / metabolite / urea-cycle intermediate / arginine precursor

Function: Citrulline is a non-protein amino acid involved in the urea cycle and arginine metabolism. It can be converted with aspartate to argininosuccinate by ASS1 and subsequently to arginine by ASL. Citrulline therefore contributes to endogenous arginine synthesis and indirectly influences nitric oxide production, polyamine metabolism, and cellular nitrogen balance.

Cancer: ↕ Context-dependent. Citrulline is closely linked to tumor arginine metabolism. Many cancers have reduced or absent ASS1 expression and therefore have limited ability to convert citrulline into arginine, contributing to dependence on extracellular arginine. Arginine-depletion therapies such as pegylated arginine deiminase convert arginine to citrulline and can therefore increase circulating citrulline while selectively stressing ASS1-deficient tumor cells.

Alzheimer's Disease: ↑ Circulating citrulline has been reported to be increased in Alzheimer's disease and dementia and may reflect altered arginine, nitric-oxide, and urea-cycle metabolism. Increased citrulline has also been reported across the progression from cognitively healthy subjects through mild cognitive impairment to Alzheimer's disease.
Scientific Papers found: Click to Expand⟱
8111- L-Orn,    Ornithine and its role in metabolic diseases: An appraisal
- Review, Nor, NA
*other↝, *ODC1↝, *proline↝, *polyA↝, *Cit/L-Cit↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

Cit/L-Cit↝, 1,   ODC1↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

polyA↝, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

Migration(tgid=13) ⓘ

proline↝, 1,  
Total Targets: 5

Scientific Paper Hit Count for: Cit/L-Cit, citrulline
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1763  State#:%  Dir#:4
  wNotes=0  sortOrder:rid,rpid

 

Home Page