CHOP/DDIT3 Cancer Research Results

CHOP/DDIT3, GADD153: Click to Expand ⟱
Source:
Type: Protein
DDIT3, GADD153 and CHOP (C/EBP-homologous protein) refer to the same protein. GADD153 stands for "Growth Arrest and DNA Damage-inducible protein 153," while CHOP stands for "C/EBP Homologous Protein."
DDIT3 (DNA Damage Inducible Transcript 3), also known as CHOP (C/EBP Homologous Protein), is a transcription factor that plays a significant role in the cellular response to stress, particularly in the context of the unfolded protein response (UPR) and apoptosis.

CHOP is an important component of the endoplasmic reticulum (ER) stress response. Research has shown that knockdown of CHOP not only enhances tunicamycin-induced autophagy, but also significantly attenuates ER stress-induced apoptosis in human colon cancer cells.
GADD153, also known as CHOP (C/EBP homologous protein), is a transcription factor that plays a significant role in cellular stress responses, particularly in the context of the endoplasmic reticulum (ER) stress response. It is part of the unfolded protein response (UPR), which is activated when there is an accumulation of misfolded proteins in the ER.
Scientific Papers found: Click to Expand⟱
8036- IVM,    Ivermectin inhibits the growth of ESCC by activating the ATF4-mediated endoplasmic reticulum stress-autophagy pathway
- in-vitro, ESCC, KYSE-30
*AntiP↑, Ivermectin is a broad-spectrum antiparasitic drug with notable antitumor activity.
AntiTum↑,
ER Stress↑, we elucidate the role of ivermectin in ESCC suppression by activating the endoplasmic reticulum (ER) stress and autophagy pathways.
TumAuto↑,
ATF4↑, activating transcription factor 4 (ATF4) and DNA damage inducible transcript 3 (DDIT3) are involved in the activation of ER stress by ivermectin. show that ivermectin activates the expression of ATF4, a regulator of the ER stress pathway.
CHOP/DDIT3↝,
TumCG↓, ivermectin treatment suppresses the growth of ESCC xenograft tumors in nude mice.
PERK↑, Furthermore, the increase in the protein levels of PERK, CHOP, and ATF4 suggested that ER stress was induced.
ROS↑, Ivermectin induces ATF4 and autophagy through ROS generation
*toxicity↓, Ivermectin has been used in millions of parasite-infected patients and is well tolerated; therefore, it has been proven to be safe at its antiparasitic dosage
Ca+2↑, We demonstrated here that ivermectin activated ER stress and increased ROS and Ca 2+ levels in ESCC cells.

1100- LT,    Luteolin, a flavonoid, as an anticancer agent: A review
- Review, NA, NA
TumCP↓,
TumCCA↑,
Apoptosis↑,
EMT↓, reverse epithelial-mesenchymal transition (EMT)
E-cadherin↑,
N-cadherin↓,
Snail↓,
Vim↓,
ROS↑, Luteolin increases levels of intracellular reactive oxygen species (ROS) by activation
ER Stress↑,
mtDam↑, mitochondrial dysfunction
p‑eIF2α↝,
p‑PERK↝,
p‑CHOP/DDIT3↝,
p‑ATF4↝,
cl‑Casp12↝,


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   cl‑Casp12↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↝, 1,   p‑CHOP/DDIT3↝, 1,   p‑eIF2α↝, 1,   ER Stress↑, 2,   PERK↑, 1,   p‑PERK↝, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,   TumCG↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   E-cadherin↑, 1,   N-cadherin↓, 1,   Snail↓, 1,   TumCP↓, 1,   Vim↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

ATF4↑, 1,   p‑ATF4↝, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,  
Total Targets: 23

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiP↑, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,  
Total Targets: 2

Scientific Paper Hit Count for: CHOP/DDIT3, GADD153
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

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