ChrMod Cancer Research Results

ChrMod, Chromatin modification: Click to Expand ⟱
Source: CGL-CF
Type:
Genes encode proteins that directly regulate chromatin through modification of histones or DNA. Examples include the histones HIST1H3B and H3F3A, as well as the proteins DNMT1 and TET1, which covalently modify DNA, EZH2, SETD2, and KDM6A, which, in turn, methylate or demethylate histones (53–57).
Chromatin modifications are critical regulators of gene expression and play significant roles in cancer development and progression. Dysregulation of these modifications can lead to the silencing of tumor suppressor genes, activation of oncogenes, and genomic instability.
Scientific Papers found: Click to Expand⟱
326- AgNPs,  TSA,    Modulating chromatin structure and DNA accessibility by deacetylase inhibition enhances the anti-cancer activity of silver nanoparticles
- in-vitro, Cerv, HeLa
Apoptosis↑,
ChrMod↝, effect on chromatin condensation
eff↑, combinational effect of HDAC inhibition and AgNP administration in HeLa cervical cancer cells

8045- IVM,    Ivermectin induces cell cycle arrest and apoptosis of HeLa cells via mitochondrial pathway
- in-vitro, Cerv, HeLa
tumCV↓, Ivermectin can inhibit the viability of HeLa cells significantly.
TumCCA↑, resulted in cell cycle arrest at the G1/S phase
DNA-PK↑, DNA fragmentation and chromatin condensation
ChrMod↝,
MMP↓, we observed that the mitochondrial membrane potential collapses and the ratio of Bax/Bcl‐2 in the cytoplasm increases, which induces cytochrome c release from the mitochondria to the cytoplasm, activates caspase‐9/‐3
Bax:Bcl2↑,
Cyt‑c↓,
Casp9↑,
Casp3↑,
ROS↑, IVM can significantly increase intracellular ROS content.
TumCMig↓, IVM can significantly inhibit the migration of HeLa cells.


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   Bax:Bcl2↑, 1,   Casp3↑, 1,   Casp9↑, 1,   Cyt‑c↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ChrMod↝, 2,   tumCV↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNA-PK↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Migration(tgid=13) ⓘ

TumCMig↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ChrMod, Chromatin modification
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:60  State#:%  Dir#:4
  wNotes=on  sortOrder:rid,rpid

 

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