Albumin Cancer Research Results

Albumin, Albumin: Click to Expand ⟱
Source:
Type: protein
Albumin is a protein found in the blood that plays a crucial role in maintaining various bodily functions, including blood volume, blood pressure, and the transport of hormones, vitamins, and minerals.
Associated with improved prognosis in certain types of cancer.
May be a marker of improved nutritional status and reduced inflammation in cancer patients.
Albumin is the most abundant plasma protein, synthesized by the liver. Biologically, it maintains oncotic pressure, transports hormones/drugs, and buffers redox and metabolic stress.

In oncology, serum albumin is a host-state biomarker, not a tumor marker.

What Low Albumin Means in Cancer
-Hypoalbuminemia reflects a convergence of cancer-relevant processes:
-Chronic inflammation (IL-6 suppresses hepatic albumin synthesis)
-Catabolism and cachexia
-Poor nutritional reserve
-Liver synthetic stress
-Advanced systemic disease

Low albumin is therefore a global severity signal, not a single-pathway readout.


Scientific Papers found: Click to Expand⟱
6353- DRE,  Cisplatin,    Insights Into Protective Mechanisms of Dandelion Leaf Extract Against Cisplatin-Induced Nephrotoxicity in Rats: Role of Inhibitory Effect on Inflammatory and Apoptotic Pathways
- in-vivo, Nor, NA
*antiOx↑, Several studies demonstrated the antioxidant, anti-inflammatory, and antiapoptotic effects of dandelion leaf extract (DLE);
*Inflam↓,
*Apoptosis↓,
*NF-kB↓, DLE reduced nuclear factor-κB and cytochrome c expression, and DNA fragmentation
*Cyt‑c↓,
*DNAdam↓,
*GSH↑, also maintained levels of reduced glutathione, superoxide dismutase, and serum albumin.
*SOD↑,
*Albumin↝,
*creat↓, Treatment with DLE + CP maintained the levels of creatinine at all different DLE doses.
*BUN↓, Treatment with DLE + CP significantly ameliorated the elevated levels of creatinine and BUN.
*RenoP↑, These results demonstrate that DLE administration protected the kidney from renal injury that could occur by CP injection.
*lipid-P↓, The DLE pretreated rats showed a significant decline in LPO levels compared to that observed with CP treatment alone
*TNF-α↓, DLE alone decreased the levels of TNF-α by 15% of control levels. Rats treated with DLE prior to CP exhibited a significant (P < .001) suppression in the levels of TNF-α compared to CP-treated rats.
*Casp3↓, animals treated with DLE prior to CP administration showed significant decrease in caspase-9 and caspase-3 to levels comparable to the control and compared to rats treated with CP alone
*Casp9↓,
*chemoP↑, nephroprotective activity of DLE against CP-induced nephrotoxicity.


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   GSH↑, 1,   lipid-P↓, 1,   SOD↑, 1,  

Core Metabolism/Glycolysis ⓘ

BUN↓, 1,  

Cell Death ⓘ

Apoptosis↓, 1,   Casp3↓, 1,   Casp9↓, 1,   Cyt‑c↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Clinical Biomarkers ⓘ

Albumin↝, 1,   creat↓, 1,  

Functional Outcomes ⓘ

chemoP↑, 1,   RenoP↑, 1,  
Total Targets: 17

Scientific Paper Hit Count for: Albumin, Albumin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:690  State#:%  Dir#:4
  wNotes=on  sortOrder:rid,rpid

 

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