Database Query Results : Ivermectin, ,

IVM, Ivermectin: Click to Expand ⟱
Features:
Medication that treats some parasitic diseases
Scientific Papers found: Click to Expand⟱
1070- IVM,    Ivermectin accelerates autophagic death of glioma cells by inhibiting glycolysis through blocking GLUT4 mediated JAK/STAT signaling pathway activation
- vitro+vivo, GBM, NA
TumCG↓, LC3II↑, p62↓, ATP↓, Pyruv↓, GlucoseCon↑, HK2↓, PFK1↓, GLUT4↓, Glycolysis↓, JAK2↓, p‑STAT3↓, p‑STAT5↓,
1166- IVM,    The importin α/β-specific inhibitor Ivermectin affects HIF-dependent hypoxia response pathways
- in-vitro, NA, NA
importin α/β↓, Hif1a↓,
1167- IVM,    The river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT-TCF pathway responses in human cancer
- vitro+vivo, NA, NA
Wnt↓, TCF↓, TumCP↓, Apoptosis↑, β-catenin/ZEB1↓, cycD1/CCND1↓,
1168- IVM,  SRF,    Ivermectin synergizes sorafenib in hepatocellular carcinoma via targeting multiple oncogenic pathways
- in-vitro, HCC, NA
TumMeta↓, mTOR↓, EMT↓, CSCsMark↓, STAT3↓,
1175- IVM,  PDT,    Drug induced mitochondria dysfunction to enhance photodynamic therapy of hypoxic tumors
- in-vitro, Var, NA
Hypoxia↓, mitResp↓, ROS↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   mitResp↓, 1,  

Core Metabolism/Glycolysis ⓘ

GlucoseCon↑, 1,   Glycolysis↓, 1,   HK2↓, 1,   PFK1↓, 1,   Pyruv↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,  

Autophagy & Lysosomes ⓘ

LC3II↑, 1,   p62↓, 1,  

DNA Damage & Repair ⓘ

importin α/β↓, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

CSCsMark↓, 1,   EMT↓, 1,   mTOR↓, 1,   STAT3↓, 1,   p‑STAT3↓, 1,   p‑STAT5↓, 1,   TCF↓, 1,   TumCG↓, 1,   Wnt↓, 1,  

Migration ⓘ

TumCP↓, 1,   TumMeta↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,   Hypoxia↓, 1,  

Barriers & Transport ⓘ

GLUT4↓, 1,  

Immune & Inflammatory Signaling ⓘ

JAK2↓, 1,  
Total Targets: 29

Pathway results for Effect on Normal Cells:


Total Targets: 0

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:10  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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