| Features: Sourced from apricot kernels |
| Banned in some states. May cause cyanide poisoning. Laetrile B17 (Amygdalin ) Summary: -Activation of the caspase-3 protease and downregulating Bcl-2, upregulates BAX -Bax-to-Bcl-2 ratio and caspase-3 activity were increased -Inhibits NF-kβ and NLRP3 signaling pathways -Release of cyanide through the decomposition of amygdalin by the gut microfloral B-glucosidase enzyme. (bad) -IV might be better to avoid the digestive tract which could convert to hydrogen cyanide.???? Selective Toxicity (some challenges to this statement) The amygdalin itself is not toxic, but the HCN released from it causes the amygdalin toxic effect [35]. Cancer cells are dominant in anaerobic glycolysis and β -glucosidase is at its highest activity in lactate-induced acidic conditions [36]. Therefore, cancer cells have a high level of the unlocking enzyme β -glucosidase activity that breaks down amygdalin, leading to the release of HCN On the other hand, normal cells are normo-oxygenated and contain low levels of the β -glucosidase enzyme as well as high levels of rhodanese enzyme which transforms hydrogen cyanide into harmless thiocyanate [46, 47]. Thiocyanate has positive effects on organisms such as lowering blood pressure and is also considered a precursor for vitamin B12. It is poisonous when combined with plant-rich beta-glucosidase. Upon ingestion, amygdalin is hydrolyzed to cyanide by beta-glucuronidase in the small intestine [2]. Oral intake of 500 mg of amygdalin may contain as much as 30 mg of cyanide [3]. Oral amygdalin is estimated to be 40 times more potent than intravenous form due to its enzymatic conversion to hydrogen cyanide in the gastrointestinal tract [4]. |
| 859- | Lae, | Vitamin B17 and its Proposed Application in Treating Cancer |
| - | Analysis, | NA, | NA |
| 860- | Lae, | Amygdalin as a Promising Anticancer Agent: Molecular Mechanisms and Future Perspectives for the Development of New Nanoformulations for Its Delivery |
| - | Review, | NA, | NA |
| 861- | Lae, | Chit, | SNP, | Synthesis of polygonal chitosan microcapsules for the delivery of amygdalin loaded silver nanoparticles in breast cancer therapy |
| 862- | Lae, | Molecular mechanism of amygdalin action in vitro: review of the latest research |
| - | Review, | NA, | NA |
| 863- | Lae, | Amygdalin inhibits the growth of renal cell carcinoma cells in vitro |
| - | in-vitro, | RCC, | NA |
| 864- | Lae, | Can Amygdalin Provide any Benefit in Integrative Anticancer Treatment? |
| - | Review, | NA, | NA |
| 865- | Lae, | Amygdalin: A Review on Its Characteristics, Antioxidant Potential, Gastrointestinal Microbiota Intervention, Anticancer Therapeutic and Mechanisms, Toxicity, and Encapsulation |
| 866- | Lae, | Amygdalin from Apricot Kernels Induces Apoptosis and Causes Cell Cycle Arrest in Cancer Cells: An Updated Review |
| - | Review, | NA, | NA |
| 867- | Lae, | Effects of the Gut microbiota on Amygdalin and its use as an anti-cancer therapy: Substantial review on the key components involved in altering dose efficacy and toxicity |
| - | Review, | NA, | NA |
| 868- | Lae, | The Postulated Mechanism of Action of Amygdalin (Vitamin B17) on Cancer Cells |
| - | Review, | NA, | NA |
| 869- | Lae, | Recent updates and future perspectives about amygdalin as a potential anticancer agent: A review |
| 870- | Lae, | Physician Beware: Severe Cyanide Toxicity from Amygdalin Tablets Ingestion |
| - | Case Report, | NA, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
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