Database Query Results : Propyl gallate, ,

PG, Propyl gallate: Click to Expand ⟱
Features:
An ester formed by the condensation of gallic acid and propanol.
Propyl gallate (PG), chemically known as propyl-3,4,5-trihydroxybenzoate, is widely present in processed food and cosmetics, hair products, and lubricants.
PG alone demonstrated antioxidative and cytoprotective properties against cellular damage and gained a pro-oxidative property in combination with copper (II). It was reported that PG was one of the most active compounds capable of generating H2O2 in DMEM media
Scientific Papers found: Click to Expand⟱
1763- PG,    Generation of Hydrogen Peroxide in Cancer Cells: Advancing Therapeutic Approaches for Cancer Treatment
- Review, NA, NA
*antiOx↑, *ROS↓, *ROS↑,
1764- PG,  Cu,    DNA strand break induction and enhanced cytotoxicity of propyl gallate in the presence of copper(II)
- in-vitro, Nor, GM05757
*DNAdam↑, *ROS↑, *Dose∅, *DNAdam∅,
1765- PG,    Enhanced cell death effects of MAP kinase inhibitors in propyl gallate-treated lung cancer cells are related to increased ROS levels and GSH depletion
- in-vitro, Lung, A549 - in-vitro, Lung, Calu-6
TumCD↑, MMP↓, ROS↑, GSH↓, Dose∅, eff↑,
1766- PG,    Propyl gallate induces human pulmonary fibroblast cell death through the regulation of Bax and caspase-3
- in-vitro, Nor, NA
TumCCA↑, MMP↓,
1767- PG,    Propyl gallate induces cell death in human pulmonary fibroblast through increasing reactive oxygen species levels and depleting glutathione
- in-vitro, Nor, NA
*ROS↑, *GSH↓, *SOD↓, *Catalase↓, eff↓,
1768- PG,    Propyl gallate reduces the growth of lung cancer cells through caspase‑dependent apoptosis and G1 phase arrest of the cell cycle
- in-vitro, Lung, Calu-6 - in-vitro, Lung, A549
TumCG↓, TumCCA↓, Dose∅, Bcl-2↓, cl‑PARP↑, MMP↓, Casp3↑, Casp8↑,
1769- PG,    The Anti-Apoptotic Effects of Caspase Inhibitors in Propyl Gallate-Treated Lung Cancer Cells Are Related to Changes in Reactive Oxygen Species and Glutathione Levels
- in-vitro, Lung, Calu-6 - in-vitro, Lung, A549
TumCP↓, eff↑, ROS↑, GSH↑,
1770- PG,    Propyl gallate sensitizes human lung cancer cells to cisplatin-induced apoptosis by targeting heme oxygenase-1 for TRC8-mediated degradation
- in-vitro, Lung, NA
antiOx↑, Inflam↓, HO-1↓, eff↑, ChemoSen↑,
1771- PG,    Pharmacokinetic and toxicological overview of propyl gallate food additive
- Human, Nor, NA
*toxicity∅,
1772- PG,    Propyl gallate decreases the proliferation of Calu-6 and A549 lung cancer cells via affecting reactive oxygen species and glutathione levels
- in-vitro, Lung, Calu-6 - in-vitro, Lung, A549
ROS⇅, TumCP↓, GSH↓,
1774- PG,    Geno- and cytotoxicity of propyl gallate food additive
- in-vitro, Lung, A549
TumCG↓, Dose∅, DNAdam↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 11

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   GSH↓, 2,   GSH↑, 1,   HO-1↓, 1,   ROS↑, 2,   ROS⇅, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 3,  

Cell Death ⓘ

Bcl-2↓, 1,   Casp3↑, 1,   Casp8↑, 1,   TumCD↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 2,  

Migration ⓘ

TumCP↓, 2,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   Dose∅, 3,   eff↓, 1,   eff↑, 3,  
Total Targets: 22

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↓, 1,   GSH↓, 1,   ROS↓, 1,   ROS↑, 3,   SOD↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   DNAdam∅, 1,  

Drug Metabolism & Resistance ⓘ

Dose∅, 1,  

Functional Outcomes ⓘ

toxicity∅, 1,  
Total Targets: 10

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:138  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page