Database Query Results : Zinc, ,

Z, Zinc: Click to Expand ⟱
Features:
Zinc is an essential mineral that supports immune function, wound healing, skin health, and more.

Zinc is an essential cofactor for many enzymes, including superoxide dismutase (SOD), which scavenges free radicals and limits oxidative stress—a known contributor to DNA damage and cancer initiation.

Maintaining adequate zinc status (typically, serum concentrations within a normal reference range of roughly 70–120 µg/dL) is important for overall health, while both deficiency and excessive intake may have implications for cancer risk.

Some zinc-dependent enzymes, such as histone deacetylases (HDACs) or components of chromatin remodeling complexes, rely on zinc for their function.

Zinc can modulate several intracellular signaling cascades. For example, zinc ions may affect the activity of protein kinases and phosphatases.

Evidence suggests that alterations in zinc levels can impact growth factor signaling pathways, which are vital in controlling cell growth and survival and are often dysregulated in cancer.

Zinc is involved in the regulation of cell cycle progression and apoptosis (programmed cell death). It can modulate the activity of several transcription factors (e.g., p53) that regulate growth arrest and apoptosis in response to cellular stress.
Scientific Papers found: Click to Expand⟱
5013- DSF,  Cu,  Z,    Disulfiram inhibits activating transcription factor/cyclic AMP-responsive element binding protein and human melanoma growth in a metal-dependent manner in vitro, in mice and in a patient with metastatic disease
- vitro+vivo, Melanoma, NA - Case Report, Melanoma, NA
P-gp↓, NF-kB↓, ChemoSen↑, angioG↓, TumCG↓, TumMeta↓, Remission↑, toxicity↓, ATF2↓, CREB↓, cycA1/CCNA1↓, TumCG↓, angioG↓, Dose↝, toxicity↝,
1407- GoldNP,  Z,    The antioxidant effects of silver, gold, and zinc oxide nanoparticles on male mice in in vivo condition
- in-vivo, NA, NA
ROS↑, GPx↓, Catalase↓,
2538- SNP,  SDT,  Z,    Dual-functional silver nanoparticle-enhanced ZnO nanorods for improved reactive oxygen species generation and cancer treatment
- Study, Var, NA - vitro+vivo, NA, NA
ROS↑, eff↑, eff↑, TumCP↓, toxicity↓,
961- Z,    Zinc Downregulates HIF-1α and Inhibits Its Activity in Tumor Cells In Vitro and In Vivo
- in-vitro, RCC, RCC4 - vitro+vivo, GBM, U373MG - in-vitro, Nor, HUVECs
Hif1a↓, HIF-1↓, VEGF↓, TumCI↓,
1221- Z,    Unexpected zinc dependency of ferroptosis: what is in a name?
- Analysis, Nor, NA
*Ferroptosis↑, *ROS↑, *lipid-P↑,
1222- Z,    Zinc regulates primary ovarian tumor growth and metastasis through the epithelial to mesenchymal transition
- in-vitro, Ovarian, NA
EMT↑, TumCMig↑, TumCI↑, ERK↑, Akt↑,
4084- Z,    Role of micronutrients in Alzheimer's disease: Review of available evidence
- Review, AD, NA
*neuroP↑, *cognitive↑, *AChE↓, *memory↑,
4164- Z,    Zinc treatment induces cortical brain-derived neurotrophic factor gene expression
- Review, AD, NA
*BDNF↑,
4165- Z,    Antidepressant-like activity of zinc: further behavioral and molecular evidence
- in-vivo, AD, NA
*BDNF↑,
4166- Z,    Zinc monotherapy increases serum brain-derived neurotrophic factor (BDNF) levels and decreases depressive symptoms in overweight or obese subjects: a double-blind, randomized, placebo-controlled trial
- Trial, Obesity, NA
*BDNF↑, *Mood↑,
4196- Z,    The effect of zinc supplementation on brain derived neurotrophic factor: A meta-analysis
- Review, NA, NA
*BDNF∅,
4197- Z,    The Effect of Zinc Supplementation on Circulating Levels of Brain-Derived Neurotrophic Factor (BDNF): A Systematic Review and Meta-Analysis of Randomized Controlled Trials
- Review, NA, NA
*BDNF↑, *other↓, *eff↑, *Inflam↓, *antiOx↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 12

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↓, 1,   GPx↓, 1,   ROS↑, 2,  

Core Metabolism/Glycolysis ⓘ

CREB↓, 1,  

Cell Death ⓘ

Akt↑, 1,   ATF2↓, 1,  

Cell Cycle & Senescence ⓘ

cycA1/CCNA1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↑, 1,   ERK↑, 1,   TumCG↓, 2,  

Migration ⓘ

TumCI↓, 1,   TumCI↑, 1,   TumCMig↑, 1,   TumCP↓, 1,   TumMeta↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   HIF-1↓, 1,   Hif1a↓, 1,   VEGF↓, 1,  

Barriers & Transport ⓘ

P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   Dose↝, 1,   eff↑, 2,  

Functional Outcomes ⓘ

Remission↑, 1,   toxicity↓, 2,   toxicity↝, 1,  
Total Targets: 27

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Ferroptosis↑, 1,   lipid-P↑, 1,   ROS↑, 1,  

Cell Death ⓘ

Ferroptosis↑, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,   BDNF↑, 4,   BDNF∅, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  

Functional Outcomes ⓘ

cognitive↑, 1,   memory↑, 1,   Mood↑, 1,   neuroP↑, 1,  
Total Targets: 15

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:170  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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