Database Query Results : chitosan, ,

Chit, chitosan: Click to Expand ⟱
Features:
Chitosan is a naturally occurring polysaccharide derived from the exoskeletons of crustaceans, such as crabs and shrimp.
Chitosan has been shown to inhibit the growth of various types of cancer cells, including breast, lung, and colon cancer cells.
Chitosan has been shown to inhibit angiogenesis, stimulate the immune system, and anti-inflammatory.

Chitosan is only soluble in acidic settings, hence limiting its use in neutral or alkaline pH circumstances


Scientific Papers found: Click to Expand⟱
1405- BBR,  Chit,    Chitosan/alginate nanogel potentiate berberine uptake and enhance oxidative stress mediated apoptotic cell death in HepG2 cells
- in-vitro, Liver, HepG2
*BioAv↑, ROS↑, MMP↓, TumCP↓,
4475- Chit,    Cholesterol-lowering properties and safety of chitosan
- Review, Nor, NA
*Weight↝, *LDL↓,
4487- Chit,  PreB,    Unravelling the Role of Chitin and Chitosan in Prebiotic Activity and Correlation With Cancer: A Narrative Review
- Review, NA, NA
*GutMicro↑, Apoptosis↑, BAX↑, Bcl-2↓, *Inflam↓, AntiTum↑,
4489- Chit,  Se,    Inhibiting Metastasis and Improving Chemosensitivity via Chitosan-Coated Selenium Nanoparticles for Brain Cancer Therapy
- in-vitro, GBM, U87MG
TumCG↓, TumCMig↓, TumCI↓, ChemoSen↑, *BBB↑, eff↑, eff↑, eff↑, selectivity↑, MMP2↓, MMP9↓, EPR↑,
4482- Chit,    Hyaluronic acid-coated chitosan nanoparticles induce ROS-mediated tumor cell apoptosis and enhance antitumor efficiency by targeted drug delivery via CD44
- in-vitro, Lung, A549 - in-vitro, Liver, HepG2
EPR↑, mtDam↑, ROS↑, Apoptosis↑,
4481- Chit,    Antioxidant Properties and Redox-Modulating Activity of Chitosan and Its Derivatives: Biomaterials with Application in Cancer Therapy
- Review, Var, NA
*BioAv↑, *toxicity↓, *antiOx↑, AntiCan↑, *Inflam↓, *ROS↓, *lipid-P↓, MDA↓, selectivity↑, MMP↓, ROS↑, TumCCA↑, MDA↑, GSH↓, ChemoSen↑,
4490- Chit,  FA,    Chitosan Nanoparticle-Based Drug Delivery Systems: Advances, Challenges, and Future Perspectives
- Review, NA, NA
EPR↑, *BioAv↑, *eff↑, *other↝, *Insulin↑, *Bacteria↓, eff↑, ChemoSen↑,
4479- Chit,    Chitosan nanoparticles triggered the induction of ROS-mediated cytoprotective autophagy in cancer cells
- in-vitro, Cerv, HeLa - in-vitro, HCC, SMMC-7721 cell
TumAuto↑, ROS↑, eff↓,
4478- Chit,    Chitosan promotes ROS-mediated apoptosis and S phase cell cycle arrest in triple-negative breast cancer cells: evidence for intercalative interaction with genomic DNA
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7 - in-vitro, BC, T47D
TumCP↓, selectivity↑, MMP↓, ROS↑, TumCCA↑, Apoptosis↑, Casp3↑,
4477- Chit,    Recent Advances in Chitosan and its Derivatives in Cancer Treatment
- Review, NA, NA
*BioAv↑, AntiTum↑, eff↑, TumCG↓, angioG↓, TumMeta↓, eff↑, *toxicity↓, other↝,
4476- Chit,    Chitosan decreases total cholesterol in women: a randomized, double-blind, placebo-controlled trial
- Trial, NA, NA
*LDL↓,
4493- Chit,  Selenate,  Se,    A novel synthetic chitosan selenate (CS) induces apoptosis in A549 lung cancer cells via the Fas/FasL pathway
- in-vitro, Lung, A549
tumCV↓, Apoptosis↑, TumCCA↑, Fas↑, FasL↑, FADD↑, Casp↑,
428- Chit,  docx,  CUR,    Chitosan-based nanoparticle co-delivery of docetaxel and curcumin ameliorates anti-tumor chemoimmunotherapy in lung cancer
- vitro+vivo, Lung, H460 - vitro+vivo, Lung, H1299 - vitro+vivo, Lung, A549 - vitro+vivo, Lung, PC9
MDSCs↓, TregCell↓, IL10↓, NK cell↑,
4597- GoldNP,  Chit,    Influence of chitosan coating on the oral bioavailability of gold nanoparticles in rats
- in-vivo, NA, NA
*BioAv↑,
861- Lae,  Chit,  SNP,    Synthesis of polygonal chitosan microcapsules for the delivery of amygdalin loaded silver nanoparticles in breast cancer therapy
other↑,
1795- LEC,  Chit,    Self-assembled lecithin-chitosan nanoparticles improve the oral bioavailability and alter the pharmacokinetics of raloxifene
- in-vivo, Nor, NA
eff↑, BioAv↑,
2968- PL,  Chit,    Preparation of piperlongumine-loaded chitosan nanoparticles for safe and efficient cancer therapy
- in-vitro, GC, AGS
eff↑, Dose↝, ROS↑, BioAv↑,
4604- Se,  SNP,  Chit,    The ameliorative effect of selenium-loaded chitosan nanoparticles against silver nanoparticles-induced ovarian toxicity in female albino rats
- in-vivo, Nor, NA
*Dose↝, *GSH↑, *SOD↑, *toxicity↓,
4491- Se,  Chit,  VitC,    Synthesis of a Bioactive Composition of Chitosan–Selenium Nanoparticles
- Study, NA, NA
*ROS↓, *selenoP↑, *antiOx↑, *Inflam↓, *Risk↓, *toxicity↓, AntiTum↑, Dose↝,
4504- Se,  Chit,  FA,  doxoR,    pH-responsive selenium nanoparticles stabilized by folate-chitosan delivering doxorubicin for overcoming drug-resistant cancer cells
- in-vitro, Var, NA
ChemoSen↑, Apoptosis↑, Casp3↑, PARP↝,
4488- Se,  Chit,  PEG,    Anticancer effect of selenium/chitosan/polyethylene glycol/allyl isothiocyanate nanocomposites against diethylnitrosamine-induced liver cancer in rats
- in-vivo, Liver, HepG2 - in-vivo, Nor, HL7702
tumCV↓, Apoptosis↑, *GSH↑, *VitC↑, *VitE↑, *SOD↑, *GPx↑, *GR↑, ALAT↓, ALP↓, AST↓, LDH↓, selectivity↑, eff↑,
4484- Se,  Chit,  PEG,    Anti-cancer potential of selenium-chitosan-polyethylene glycol-carvacrol nanocomposites in multiple myeloma U266 cells
- in-vitro, Melanoma, U266
tumCV↓, selectivity↑, ROS↑, MMP↓, Apoptosis↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓,
4483- Se,  Chit,    Anti-cancer potential of chitosan-starch selenium Nanocomposite: Targeting osteoblastoma and insights of molecular docking
- in-vitro, OS, NA
AntiCan↑, TumCP↓, Apoptosis↑, ROS↑, eff↑, other↝, eff↑, TumCCA↑,
4480- Se,  Chit,    Biogenic synthesized selenium nanoparticles combined chitosan nanoparticles controlled lung cancer growth via ROS generation and mitochondrial damage pathway
- in-vitro, Lung, A549 - in-vitro, Nor, HK-2
selectivity↑, *toxicity↓, ROS↑, mtDam↑, Apoptosis↑, LDH↑,
4470- Se,  Chit,    Synthesis and cytotoxic activities of selenium nanoparticles incorporated nano-chitosan
- in-vitro, CRC, HCT116 - in-vitro, Liver, HepG2 - in-vitro, BC, MCF-7
Dose↝, AntiCan↑, eff↑,
4467- Se,  VitC,  Chit,    Nano-chitosan-coated, green-synthesized selenium nanoparticles as a novel antifungal agent against Sclerotinia sclerotiorum in vitro study
- Study, NA, NA
*Dose↝, *Dose↝,
4452- Se,  Chit,    Antioxidant capacities of the selenium nanoparticles stabilized by chitosan
- in-vitro, Nor, 3T3
*toxicity↓, *antiOx↑, *GPx↑, *ROS↓,
4486- Se,  Chit,    Selenium-Modified Chitosan Induces HepG2 Cell Apoptosis and Differential Protein Analysis
- in-vitro, Liver, HepG2
Apoptosis↑, TumCCA↑, MMP↓, Bcl-2↓, BAX↑, cl‑Casp9↑, cl‑Casp3↑, Risk↓, *BioAv↑, *toxicity↑, TumCG↓, AntiTum↑, ROS↑, Cyt‑c↑, Fas↑, FasL↑, FADD↑,
380- SNP,  QC,  CA,  Chit,    Quercetin- and caffeic acid-functionalized chitosan-capped colloidal silver nanoparticles: one-pot synthesis, characterization, and anticancer and antibacterial activities
- in-vitro, MG, U118MG
TumCG↓,
4399- SNP,  Chit,    Silver nanoparticles impregnated alginate-chitosan-blended nanocarrier induces apoptosis in human glioblastoma cells
- in-vitro, GBM, U87MG
DNAdam↑, ROS↑, MMP↓, eff↑,
4593- SNP,  Chit,    Chitosan-coated silver nanoparticles promoted antibacterial, antibiofilm, wound-healing of murine macrophages and antiproliferation of human breast cancer MCF 7 cells
- in-vitro, BC, MCF-7
*Bacteria↓, *Wound Healing↑, TumCG↓,
4592- SNP,  Chit,    Chitosan conjugated silver nanoparticles: the versatile antibacterial agents
- in-vitro, NA, NA
*Bacteria↓,
4591- SNP,  Chit,    Synthesis and Characterization of Multifunctional Chitosan–Silver Nanoparticles: An In-Vitro Approach for Biomedical Applications
- in-vitro, NA, NA
*Bacteria↓, *Wound Healing↑,
4590- SNP,  Chit,    Silver nanochitosan: a sustainable approach for enhanced antimicrobial, antioxidant, and anticancer applications
- in-vitro, NA, NA
*Bacteria↓, *Wound Healing↑,
4589- SNP,  Chit,    Synthesis and Characterization of Chitosan–Silver Nanocomposite Film: Antibacterial and Cytotoxicity Study
- in-vitro, NA, NA
*Bacteria↓,
4588- SNP,  Chit,    Solid-state tailored silver nanocomposites from chitosan: Synthesis, antimicrobial evaluation and molecular docking
- in-vitro, NA, NA
*Bacteria↓,
4587- SNP,  Chit,    Multifunctional Silver Nanoparticles Based on Chitosan: Antibacterial, Antibiofilm, Antifungal, Antioxidant, and Wound-Healing Activities
- in-vitro, NA, NA
*Bacteria↓, *Wound Healing↑,
4548- SNP,  Chit,    Synergistic combination of antioxidants, silver nanoparticles and chitosan in a nanoparticle based formulation: Characterization and cytotoxic effect on MCF-7 breast cancer cell lines
- in-vitro, BC, MCF-7
AntiCan↑, EPR↑, pH↝,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 38

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress

GSH↓, 1,   MDA↓, 1,   MDA↑, 1,   ROS↑, 11,  

Mitochondria & Bioenergetics

MMP↓, 6,   mtDam↑, 2,  

Core Metabolism/Glycolysis

ALAT↓, 1,   LDH↓, 1,   LDH↑, 1,  

Cell Death

Apoptosis↑, 10,   BAX↑, 3,   Bcl-2↓, 3,   Casp↑, 1,   Casp3↑, 3,   cl‑Casp3↑, 1,   Casp9↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↑, 1,   FADD↑, 2,   Fas↑, 2,   FasL↑, 2,  

Transcription & Epigenetics

other↑, 1,   other↝, 2,   tumCV↓, 3,  

Autophagy & Lysosomes

TumAuto↑, 1,  

DNA Damage & Repair

DNAdam↑, 1,   PARP↝, 1,  

Cell Cycle & Senescence

TumCCA↑, 5,  

Proliferation, Differentiation & Cell State

TumCG↓, 5,  

Migration

MMP2↓, 1,   MMP9↓, 1,   TregCell↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 3,   TumMeta↓, 1,  

Angiogenesis & Vasculature

angioG↓, 1,   EPR↑, 4,  

Immune & Inflammatory Signaling

IL10↓, 1,   MDSCs↓, 1,   NK cell↑, 1,  

Cellular Microenvironment

pH↝, 1,  

Drug Metabolism & Resistance

BioAv↑, 2,   ChemoSen↑, 4,   Dose↝, 3,   eff↓, 1,   eff↑, 13,   selectivity↑, 6,  

Clinical Biomarkers

ALAT↓, 1,   ALP↓, 1,   AST↓, 1,   LDH↓, 1,   LDH↑, 1,  

Functional Outcomes

AntiCan↑, 4,   AntiTum↑, 4,   Risk↓, 1,  
Total Targets: 56

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress

antiOx↑, 3,   GPx↑, 2,   GSH↑, 2,   lipid-P↓, 1,   ROS↓, 3,   selenoP↑, 1,   SOD↑, 2,   VitC↑, 1,   VitE↑, 1,  

Mitochondria & Bioenergetics

Insulin↑, 1,  

Core Metabolism/Glycolysis

LDL↓, 2,  

Transcription & Epigenetics

other↝, 1,  

Barriers & Transport

BBB↑, 1,  

Immune & Inflammatory Signaling

Inflam↓, 3,  

Hormonal & Nuclear Receptors

GR↑, 1,  

Drug Metabolism & Resistance

BioAv↑, 6,   Dose↝, 3,   eff↑, 1,  

Clinical Biomarkers

GutMicro↑, 1,  

Functional Outcomes

Risk↓, 1,   toxicity↓, 6,   toxicity↑, 1,   Weight↝, 1,   Wound Healing↑, 4,  

Infection & Microbiome

Bacteria↓, 8,  
Total Targets: 25

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:210  Target#:%  State#:%  Dir#:%
wNotes=0 sortOrder:rid,rpid

 

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