Database Query Results : methotrexate, ,

MTX, methotrexate: Click to Expand ⟱
Features:
Methotrexate is a chemotherapy medication that has been used to treat various types of cancer.
Methotrexate works by:
Inhibiting dihydrofolate reductase (DHFR): Methotrexate binds to DHFR, an enzyme that is necessary for the production of tetrahydrofolate, a co-factor for DNA synthesis.
Interfering with DNA synthesis: By inhibiting DHFR, methotrexate prevents the production of tetrahydrofolate, which is necessary for DNA synthesis.
Inducing apoptosis: Methotrexate can induce apoptosis (programmed cell death) in cancer cells.
Scientific Papers found: Click to Expand⟱
1122- LF,  MTX,    Lactoferrin Reverses Methotrexate Driven Epithelial Barrier Defect by Inhibiting TGF-β Mediated Epithelial to Mesenchymal Transition
- in-vivo, Colon, Caco-2
TGF-β↓, EMT↓,
523- MF,  MTX,    Extremely low-frequency magnetic fields significantly enhance the cytotoxicity of methotrexate and can reduce migration of cancer cell lines via transiently induced plasma membrane damage
- in-vitro, AML, THP1 - in-vitro, NA, PC12 - in-vivo, Cerv, HeLa
H2O2↑, TumCD↑, CellMemb↑, eff↑,
2111- TQ,  MTX,    Effect of Nigella sativa (black seeds) against methotrexate-induced nephrotoxicity in mice
- in-vivo, Nor, NA
*RenoP↑, *GSH↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

H2O2↑, 1,  

Cell Death ⓘ

TumCD↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,  

Migration ⓘ

TGF-β↓, 1,  

Barriers & Transport ⓘ

CellMemb↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

GSH↑, 1,  

Functional Outcomes ⓘ

RenoP↑, 1,  
Total Targets: 2

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:223  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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