Database Query Results : Catechins, ,

Catechins, Catechins: Click to Expand ⟱
Features:
Catechins belong to the category of flavanols, which have two isomeric forms, a positive (+) form and a negative (−) form (epicatechin). The (+)-catechins have antioxidative properties, whereas the (−)-epicatechins act as pro-oxidants inducing oxidative effects.
(−)-epicatechins Examples: EGCG, EGC, GCG GC ECTG, EC (all found in green tea, and maybe dark chocolate)
Scientific Papers found: Click to Expand⟱
603- Catechins,    Catechins induce oxidative damage to cellular and isolated DNA through the generation of reactive oxygen species
- in-vitro, NA, HL-60
ROS↑, DNAdam↑, H2O2↑,
939- Catechins,  5-FU,    Targeting Lactate Dehydrogenase A with Catechin Resensitizes SNU620/5FU Gastric Cancer Cells to 5-Fluorouracil
- vitro+vivo, GC, SNU620
lactateProd↓, ROS↑, tumCV↓, LDHA↓, mt-ROS↑, proApCas↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

H2O2↑, 1,   ROS↑, 2,   mt-ROS↑, 1,  

Core Metabolism/Glycolysis ⓘ

lactateProd↓, 1,   LDHA↓, 1,  

Cell Death ⓘ

proApCas↑, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:228  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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