Database Query Results : Hydroxytyrosol, ,

HTyr, Hydroxytyrosol: Click to Expand ⟱
Features:
Hydroxytyrosol (HT), abundantly present in olives, has demonstrated anticancer properties. HT exhibited antiproliferative and pro-apoptotic effects in cancer cells through H2O2 generation. The mechanism of prooxidant activity of HT involves O2 and transition metals. First, the phenol moiety undergoes oxidation by Cu(II) or Fe(II), forming semiquinones, which then react with O2 generating O2•− and finally producing H2O2.
Scientific Papers found: Click to Expand⟱
601- HTyr,    Dihydroxyphenylethanol induces apoptosis by activating serine/threonine protein phosphatase PP2A and promotes the endoplasmic reticulum stress response in human colon carcinoma cells
- in-vivo, NA, HT-29
TumCG↓, Apoptosis↑, ER Stress↑, UPR↑, CHOP↑, JNK↑, TNF-α↓, PPP2R1A↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 1,   JNK↑, 1,   PPP2R1A↑, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↑, 1,   UPR↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Immune & Inflammatory Signaling ⓘ

TNF-α↓, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:229  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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