Database Query Results : PXD, phenoxodiol, ,

Phen, PXD, phenoxodiol: Click to Expand ⟱
Features:
Phenoxodiol (PXD) is a synthetic compound that has been investigated as a potential therapeutic agent for the treatment of various types of cancer.
Phenoxodiol is an inhibitor of ENOX2 (ecto-nicotinamide adenine dinucleotide oxidase 2), also known as tNOX (tumor-associated NADH oxidase).
Scientific Papers found: Click to Expand⟱
693- EGCG,  CAP,  Phen,    Metabolite modulation of HeLa cell response to ENOX2 inhibitors EGCG and phenoxodiol
- in-vitro, Cerv, HeLa
ENOX2↓, TumCG↓,
1515- EGCG,  Phen,    Reciprocal Relationship Between Cytosolic NADH and ENOX2 Inhibition Triggers Sphingolipid-Induced Apoptosis in HeLa Cells
- in-vitro, Cerv, HeLa - in-vitro, Nor, MCF10 - in-vitro, BC, BT20
selectivity↑, ENOX2↓, NADH↑, SK↓, eff↑, aSmase↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ENOX2↓, 2,   NADH↑, 1,  

Cell Death ⓘ

aSmase↑, 1,   SK↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,   selectivity↑, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:237  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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