Database Query Results : Scoulerine, ,

Sco, Scoulerine: Click to Expand ⟱
Features:
Scoulerine is an isoquinoline alkaloid found in various plants (such as members of the Menispermaceae family and in certain Corydalis species) that has attracted interest due to its potential pharmacological activities.
Both scoulerine and berberine belong to the broad family of isoquinoline alkaloids, meaning they share a similar biosynthetic origin and core chemical framework.
– Scoulerine is less commonly encountered in typical dietary sources and is mostly identified in certain herbal extracts from plants in families such as Menispermaceae or Corydalis.

structurally related benzylisoquinoline alkaloids (e.g., berberine, sanguinarine), so best to refer to those products for more information
Scientific Papers found: Click to Expand⟱
1388- Sco,    Scoulerine promotes cell viability reduction and apoptosis by activating ROS-dependent endoplasmic reticulum stress in colorectal cancer cells
- in-vitro, CRC, NA
tumCV↓, Apoptosis↑, Casp3↑, Casp7↑, BAX↑, Bcl-2↓, ROS↑, GSH↓, SOD↓, ER Stress↑, GRP78/BiP↑, CHOP↑, eff↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSH↓, 1,   ROS↑, 1,   SOD↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp7↑, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↑, 1,   GRP78/BiP↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↓, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Total Targets: 0

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:247  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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