Database Query Results : Mushroom Shiitake, AHCC, ,

MushShi, Mushroom Shiitake, AHCC: Click to Expand ⟱
Features: immunoenhancer
Mushroom Shiitake, Active hexose correlated compound
Extracted from Basidiomycete mushrooms (eg, shiitake [Lentinula edodes]) that is purported to improve immune function.
Summary:
- Can significantly inhibit carcinogenesis and improve anti-tumor effects, thus increasing the effectiveness of cancer immunotherapy.
- Enhanced abundance of Akkermansia in the intestine of those who responded positively to the ICI(immune checkpoint inhibitors).

-Eat fermented foods then fibre to maintain them. Fruits and vegs for fibre Chicory root for fibre (inulin which is main prebiotic)

AHCC is mainly derived from the mycelium of Shiitake mushrooms.
• It is rich in polysaccharides that are believed to enhance immune function.
• The compound may influence various pathways in cancer, including boosting NK cell activity, modulating cytokine production, influencing the NF-kB inflammatory pathway, and reducing oxidative stress.

Pathways:
-Stimulate cytokine production (e.g., interleukins, tumor necrosis factor) and enhance the function of macrophages and dendritic cells.
https://pubmed.ncbi.nlm.nih.gov/28727820/


Scientific Papers found: Click to Expand⟱
2- MushShi,    The Effects of Active Hexose Correlated Compound (AHCC) on Levels of CD4+ and CD8+ in Patients with Epithelial Ovarian Cancer or Peritoneal Cancer Receiving Platinum Based Chemotherapy
CD8+↑,
3- MushShi,    AHCC Activation and Selection of Human Lymphocytes via Genotypic and Phenotypic Changes to an Adherent Cell Type: A Possible Novel Mechanism of T Cell Activation
LAT↑, FLRT2↑, GIT1↑, T-Cell↑,
930- MushShi,    Active Hexose Correlated Compound (AHCC) Inhibits the Proliferation of Ovarian Cancer Cells by Suppressing Signal Transducer and Activator of Transcription 3 (STAT3) Activation
- in-vitro, Ovarian, NA
p‑STAT3↓, PTPN6↑, cycD1/CCND1↓, Bcl-2↓, Mcl-1↓, survivin↓, VEGF↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

LAT↑, 1,  

Cell Death ⓘ

Bcl-2↓, 1,   Mcl-1↓, 1,   survivin↓, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

PTPN6↑, 1,   p‑STAT3↓, 1,  

Migration ⓘ

FLRT2↑, 1,   GIT1↑, 1,  

Angiogenesis & Vasculature ⓘ

VEGF↓, 1,  

Immune & Inflammatory Signaling ⓘ

T-Cell↑, 1,  

Infection & Microbiome ⓘ

CD8+↑, 1,  
Total Targets: 12

Pathway results for Effect on Normal Cells:


Total Targets: 0

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:25  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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