Database Query Results : Selenate, ,

Selenate, Selenate: Click to Expand ⟱
Features:
Selenate shares similarity with sulfate and enters cells via sulfate transporters; however, it is less readily reduced and often considered less potent in rapid cytotoxicity effects.

Selenate tends to exhibit higher IC50 values (often in the 10–100 µM range), indicating reduced potency compared to selenite in directly inducing cancer cell death.

Less Direct ROS Generation than Selenite.
– Selenate’s toxicity is generally less acute because it is a more inert species until metabolically reduced.
– It may exert its anticancer effects once it is converted into reduced selenium species that eventually can contribute to ROS production.
Scientific Papers found: Click to Expand⟱
4493- Chit,  Selenate,  Se,    A novel synthetic chitosan selenate (CS) induces apoptosis in A549 lung cancer cells via the Fas/FasL pathway
- in-vitro, Lung, A549
tumCV↓, Apoptosis↑, TumCCA↑, Fas↑, FasL↑, FADD↑, Casp↑,
1135- Selenate,    Selenate induces epithelial-mesenchymal transition in a colorectal carcinoma cell line by AKT activation
- in-vitro, CRC, DLD1
EMT↑, Akt↑, Twist↑, Vim↑, E-cadherin↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Akt↑, 1,   Apoptosis↑, 1,   Casp↑, 1,   FADD↑, 1,   Fas↑, 1,   FasL↑, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↑, 1,  

Migration ⓘ

E-cadherin↓, 1,   Twist↑, 1,   Vim↑, 1,  
Total Targets: 12

Pathway results for Effect on Normal Cells:


Total Targets: 0

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:262  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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