Database Query Results : Vitamin B1/Thiamine, ,

VitB1/Thiamine, Vitamin B1/Thiamine: Click to Expand ⟱
Features:
VitB1/Thiamine
Benfotiamine is a fat-soluble derivative of vitamin B1 (thiamine) that’s used to support nerve health, glucose metabolism, and potentially brain function, including in conditions like Alzheimer’s disease (AD) and diabetic neuropathy.
-fat-soluble form, so may absorb better when taken with a meal containing fat.
Condition / Purpose	       Typical Dose Range	Notes
Alzheimer’s Disease (AD)	300–600 mg/day	        Used in clinical trials (e.g., 300 mg twice daily)
Diabetic Neuropathy	        300–600 mg/day	        Most common clinical application
General Cognitive Support	150–300 mg/day	        Lower end for maintenance
High-dose experimental use	900–1,200 mg/day	Occasionally used under supervision in research


Scientific Papers found: Click to Expand⟱
1888- VitB1/Thiamine,  DCA,    High Dose Vitamin B1 Reduces Proliferation in Cancer Cell Lines Analogous to Dichloroacetate
- in-vitro, PC, SK-N-BE - NA, PC, PANC1
p‑PDH↓, GlucoseCon↓, lactateProd↓, MMP↓, Casp3↑, eff↑, PDKs↓, selectivity↑, TumCG↓, Dose∅, MMP↓, ROS∅, toxicity↑, antiOx↑,
4049- VitB1/Thiamine,    Vitamin B1 (thiamine) and dementia
- Review, AD, NA
*memory↑, *p‑tau↓, *cognitive↑, *Dose↝, *Dose↓, *Aβ↓, *other↝, *eff↑, *eff↑,
4310- VitB1/Thiamine,    Pharmacological thiamine (Vitamin B1) as a treatment for alzheimer’s disease
- Review, AD, NA
*other↝, *memory↑, *Inflam↓, *p‑tau↓,
4311- VitB1/Thiamine,    Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy
- in-vivo, AD, NA
*Aβ↓, *p‑tau↓, *ROS↓, *cognitive↑, *OS↑, *Mood↑, *neuroP↑, *Inflam↓, *NRF2↑, *PGC-1α↑, *AGEs↓, *4-HNE↓, *NQO1↑, *COX2↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *GSK‐3β↓,
4312- VitB1/Thiamine,    Pharmacological thiamine levels as a therapeutic approach in Alzheimer's disease
- Review, AD, NA
*eff↑, *cognitive↑, *memory↑, *GlucoseCon↑, *Aβ↓, *Inflam↓, *antiOx↑, *p‑tau↓, *AGEs↓, *Dose↝,
4314- VitB1/Thiamine,    Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology
- Review, AD, NA
*Risk↓, *GlucoseCon↑, *cognitive↑, *ATP↑, *ROS↓, *NADPH↑, *Aβ↓, *APP↓, *BACE↓,
4327- VitB1/Thiamine,    Plasma thiamine deficiency associated with Alzheimer's disease but not Parkinson's disease
- Study, AD, NA
*Risk↓, *other↝,
1220- VitC,  VitB1/Thiamine,    The Effect of Thiamine, Ascorbic Acid, and the Combination of Them on the Levels of Matrix Metalloproteinase-9 (MMP-9) and Tissue Inhibitor of Matrix Metalloproteinase-1 (TIMP-1) in Sepsis Patients
- Trial, Sepsis, NA
MMP9:TIMP1↑, Sepsis↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   ROS∅, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 2,  

Core Metabolism/Glycolysis ⓘ

GlucoseCon↓, 1,   lactateProd↓, 1,   p‑PDH↓, 1,   PDKs↓, 1,  

Cell Death ⓘ

Casp3↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Migration ⓘ

MMP9:TIMP1↑, 1,  

Drug Metabolism & Resistance ⓘ

Dose∅, 1,   eff↑, 1,   selectivity↑, 1,  

Functional Outcomes ⓘ

toxicity↑, 1,  

Infection & Microbiome ⓘ

Sepsis↓, 1,  
Total Targets: 15

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

4-HNE↓, 1,   antiOx↑, 1,   NQO1↑, 1,   NRF2↑, 1,   ROS↓, 2,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis ⓘ

GlucoseCon↑, 2,   NADPH↑, 1,  

Transcription & Epigenetics ⓘ

other↝, 3,  

Proliferation, Differentiation & Cell State ⓘ

GSK‐3β↓, 1,  

Migration ⓘ

APP↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL1β↓, 1,   Inflam↓, 3,   NF-kB↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission ⓘ

p‑tau↓, 4,  

Protein Aggregation ⓘ

AGEs↓, 2,   Aβ↓, 4,   BACE↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↓, 1,   Dose↝, 2,   eff↑, 3,  

Functional Outcomes ⓘ

cognitive↑, 4,   memory↑, 3,   Mood↑, 1,   neuroP↑, 1,   OS↑, 1,   Risk↓, 2,  
Total Targets: 30

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:264  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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