Database Query Results : carboplatin, ,

carbop, carboplatin: Click to Expand ⟱
Features:
Carboplatin is a platinum-based chemotherapy drug, structurally related to cisplatin.
Advantages Over Cisplatin:
• Compared to cisplatin, carboplatin is associated with a more favorable side-effect profile, particularly with regard to reduced nephrotoxicity (renal toxicity).
• However, it may still cause bone marrow suppression, so careful monitoring of blood counts is essential.

Carboplatin is a key platinum-based chemotherapy agent that interferes with cancer cell DNA, leading to cell death. Its relatively favorable toxicity profile, compared to cisplatin, makes it a popular choice for treating a variety of solid tumors such as ovarian, lung, head and neck, bladder, and certain cases of testicular cancers. Due to its side-effect profile, particularly bone marrow suppression, patients receiving carboplatin require careful monitoring and dosage adjustments based on their renal function and other clinical factors.
Scientific Papers found: Click to Expand⟱
1300- GA,  PacT,  carbop,    Gallic acid potentiates the apoptotic effect of paclitaxel and carboplatin via overexpression of Bax and P53 on the MCF-7 human breast cancer cell line
- in-vitro, BC, MCF-7
TumCCA↑, Apoptosis↑, P53↑, BAX↑, Casp3↑, Bcl-2↓,
1268- NCL,  carbop,    Inhibition of Wnt/β-catenin pathway by niclosamide: a therapeutic target for ovarian cancer
- in-vitro, Ovarian, NA
Wnt/(β-catenin)↓, ALDH1A1↓, LRP6↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,  

DNA Damage & Repair ⓘ

P53↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ALDH1A1↓, 1,   LRP6↓, 1,   Wnt/(β-catenin)↓, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:265  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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