Database Query Results : Amodiaquine, ,

AMQ, Amodiaquine: Click to Expand ⟱
Features:
Amodiaquine is a synthetic 4-aminoquinoline compound initially developed as an antimalarial agent. Like chloroquine, it is based on the quinoline scaffold and was chemically synthesized rather than being directly extracted from natural products.

Pathways:
-Autophagy Inhibition:
Inhibition of autophagy and lysosomal dysfunction can lead to cellular stress through accumulation of damaged proteins and organelles, triggering pathways such as the unfolded protein response (UPR) and increasing reactive oxygen species (ROS).
Scientific Papers found: Click to Expand⟱
1440- AMQ,    Lysosomotropism depends on glucose: a chloroquine resistance mechanism
- in-vitro, BC, 4T1
eff↑, Apoptosis↓, Necroptosis↑, eff↓, ChemoSen↑, eff↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↓, 1,   Necroptosis↑, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   eff↓, 2,   eff↑, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells:


Total Targets: 0

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:272  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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