Database Query Results : acetaminophen, ,

acet, acetaminophen: Click to Expand ⟱
Features:
Acetaminophen: The most common name in the United States.
Paracetamol: The name used in most of the world.
APAP: A common abbreviation used in biochemical and pharmacological studies.

Pathways:
-Cytochrome P450 Metabolism: NAPQI (N-acetyl-p-benzoquinone imine)
-Excess NAPQI depletes glutathione, a key antioxidant. The absence of sufficient glutathione leads to elevated oxidative stress.
-NF-κB Activation:
-Direct DNA Damage:

Excess results in increased oxidative stress, mitochondrial dysfunction, and ultimately hepatocellular damage (liver injury)
Scientific Papers found: Click to Expand⟱
1478- SFN,  acet,    Anti-inflammatory and anti-oxidant effects of combination between sulforaphane and acetaminophen in LPS-stimulated RAW 264.7 macrophage cells
- in-vitro, Nor, NA
eff↑, NO↓, iNOS↓, COX2↓, IL1β↓, ROS↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↓, 1,  

Cell Death ⓘ

iNOS↓, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL1β↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:275  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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