Database Query Results : sericin, ,

sericin, sericin: Click to Expand ⟱
Features:
Sericin is a silk protein primarily obtained from the silkworm Bombyx mori and has attracted interest for its various biological properties. Some studies have investigated the potential anticancer properties of sericin.

-Sericin exhibits antioxidant properties, which may help protect cells against oxidative stress. Oxidative stress is known to contribute to the development and progression of cancer, so antioxidants are often considered beneficial in preventive strategies.
-Sericin’s anti-inflammatory effects might help reduce inflammation-related damage and potentially slow down processes that can lead to carcinogenesis.
Scientific Papers found: Click to Expand⟱
1678- PBG,  5-FU,  sericin,    In vitro and in vivo anti-colorectal cancer effect of the newly synthesized sericin/propolis/fluorouracil nanoplatform through modulation of PI3K/AKT/mTOR pathway
- in-vitro, CRC, Caco-2 - in-vivo, NA, NA
PI3K↓, Akt↓, mTOR↓, TumCP↓, Bcl-2↓, BAX↑, Casp3↑, Casp9↑, ROS↓, FOXO1↑, *toxicity∅, eff↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↓, 1,  

Cell Death ⓘ

Akt↓, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp9↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

FOXO1↑, 1,   mTOR↓, 1,   PI3K↓, 1,  

Migration ⓘ

TumCP↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Functional Outcomes ⓘ

toxicity∅, 1,  
Total Targets: 1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:282  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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