Database Query Results : Noscapine, ,

Nos, Noscapine: Click to Expand ⟱

Features:

Noscapine is a natural product. It is an isoquinoline alkaloid derived from the opium poppy (Papaver somniferum), although unlike some opium alkaloids, it does not have narcotic effects.
-Historically, it has been used as an antitussive (cough suppressant) due to its antitussive properties without causing the sedation associated with opiates.

Pathways:
-Mitochondrial stress, release of cytochrome c, and activation of caspases (such as caspase-3), leading to cellular apoptosis.
-Inhibit angiogenesis
-Interfere with the NF-κB signaling pathway

-Noscapine can enhance the effects of traditional chemotherapeutics when used in combination. It may help overcome drug resistance by modulating cell cycle regulators and apoptosis-related proteins.

Scientific Papers found: Click to Expand⟱

1911-

Nos,

Noscapine inhibits tumor growth in TMZ-resistant gliomas

in-vitro,

GBM,

in-vivo,

GBM,

animals

TumCG↓, TumCI↓, OS↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,

Migration ⓘ

TumCI↓, 1,

Functional Outcomes ⓘ

OS↑, 1,
Total Targets: 3

Pathway results for Effect on Normal Cells:

Total Targets: 0

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells