Database Query Results : Andrographis, ,

And, Andrographis: Click to Expand ⟱
Features:
Andrographis (typically referring to Andrographis paniculata).
Bitter tasting annual plant prevalent in much of Asia.
"used traditionally for the treatment of array of diseases such as cancer, diabetes, high blood pressure, ulcer, leprosy, bronchitis, skin diseases, flatulence, colic, influenza, dysentery, dyspepsia and malaria for centuries in Asia, America and Africa continents."

Andrographolide:
– Is a specific diterpenoid lactone and the major active constituent extracted from Andrographis paniculata.
– It is responsible for many of the therapeutic effects attributed to the plant, including anti-inflammatory and antioxidant properties.

A. Anti-Inflammatory Effects.
• Andrographolide has been shown to inhibit the NF-κB pathway, leading to a reduction in the transcription of inflammatory cytokines (e.g., TNF-α, IL-6).
• Andrographolide has been reported to cause cell cycle arrest at critical checkpoints (such as G0/G1 or G2/M phase) in some cancer cell models.

Andrographis, primarily through its active constituent andrographolide, offers compelling anti-inflammatory, immunomodulatory, pro-apoptotic, and antiproliferative properties. While not a standard anticancer agent, its capacity to modulate key pathways in cellular stress response and inflammation makes it an attractive candidate for complementary research in oncology.

Andrographis paniculata, also known as the "King of Bitters," is a plant native to India and Southeast Asia. Its aqueous extract, Andrographis paniculata aqueous extract (APAE), has been studied for its potential anti-cancer properties.
• Inhibition of cancer cell growth: APAE has been shown to inhibit the growth of various cancer cell lines, including breast, lung, colon, and prostate cancer cells.
• Induction of apoptosis: APAE has been found to induce apoptosis (programmed cell death) in cancer cells, which may help to prevent tumor growth and progression.
• Anti-inflammatory effects: APAE has anti-inflammatory properties, which may help to reduce the risk of cancer development and progression.
• Antioxidant activity: APAE has antioxidant activity, which may help to protect against oxidative stress and DNA damage.

Key compounds:Andrographolide, Neoandrographolide
APAE may interact with certain medications, including blood thinners and diabetes medications, and may not be suitable for individuals with certain medical conditions, such as autoimmune disorders.
Scientific Papers found: Click to Expand⟱
1279- And,    Andrographolide Exhibits Anticancer Activity against Breast Cancer Cells (MCF-7 and MDA-MB-231 Cells) through Suppressing Cell Proliferation and Inducing Cell Apoptosis via Inactivation of ER-α Receptor and PI3K/AKT/mTOR Signaling
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7
Apoptosis↑, Bcl-2↓, BAX↑, ERα/ESR1↓, PI3K↓, mTOR↓,
1354- And,    Andrographolide induces protective autophagy and targeting DJ-1 triggers reactive oxygen species-induced cell death in pancreatic cancer
- in-vitro, PC, NA - in-vivo, PC, NA
Apoptosis↑, DJ-1↓, ROS↑, TumAuto↑, TumCCA↑, TumCP↓, TumW↓, eff↓,
1353- And,    Andrographolide Induces Apoptosis and Cell Cycle Arrest through Inhibition of Aberrant Hedgehog Signaling Pathway in Colon Cancer Cells
- in-vitro, Colon, HCT116
ChemoSen↑, TumCCA↑, CDK1↓, CycB/CCNB1↓, HH↓, Smo↓, Gli1↓,
1352- And,    Andrographolide downregulates the v-Src and Bcr-Abl oncoproteins and induces Hsp90 cleavage in the ROS-dependent suppression of cancer malignancy
- in-vitro, AML, K562
Apoptosis↑, ROS↑, HSP90↓,
1351- And,  MEL,    Impact of Andrographolide and Melatonin Combinatorial Drug Therapy on Metastatic Colon Cancer Cells and Organoids
- in-vitro, CRC, T84 - in-vitro, CRC, COLO205 - in-vitro, CRC, HT-29 - in-vitro, CRC, DLD1
eff↑, Ki-67↓, Casp3↑, ER Stress↑, ROS↑, BAX↑, XBP-1↑, CHOP↑, eff↑,
1350- And,  Cisplatin,    Synergistic antitumor effect of Andrographolide and cisplatin through ROS-mediated ER stress and STAT3 inhibition in colon cancer
- in-vitro, Colon, NA
ChemoSen↑, ER Stress↑, STAT3↓, ROS↑,
1349- And,    Andrographolide promoted ferroptosis to repress the development of non-small cell lung cancer through activation of the mitochondrial dysfunction
- in-vitro, Lung, H460 - in-vitro, Lung, H1650
TumCG↓, TumMeta↓, Ferroptosis↑, ROS↑, MDA↑, Iron↑, GSH↓, GPx4↓, xCT↓, MMP↓, ATP↓,
1348- And,    Andrographolide Inhibits ER-Positive Breast Cancer Growth and Enhances Fulvestrant Efficacy via ROS-FOXM1-ER-α Axis
- in-vitro, BC, MCF-7 - in-vitro, BC, T47D - in-vivo, NA, NA
ERα/ESR1↓, TumCG↓, ROS↑, FOXM1↓, eff↑,
1347- And,    Suppression of rat neutrophil reactive oxygen species production and adhesion by the diterpenoid lactone andrographolide
- in-vitro, Nor, NA
*ROS↓,
1294- And,  5-FU,    Andrographolide reversed 5-FU resistance in human colorectal cancer by elevating BAX expression
- in-vitro, CRC, HCT116
Apoptosis↑, BAX↑,
931- And,    Effect of Andrographis Paniculata Aqueous Extract on Hyperammonemia Induced Alteration of Oxidative and Nitrosative Stress Factors in the Liver, Spleen and Kidney of Rats
- in-vivo, NA, NA
*SOD↝, *Catalase↝, *ROS↓, *MDA↓, *NO↓,
1159- And,    Andrographolide, an Anti-Inflammatory Multitarget Drug: All Roads Lead to Cellular Metabolism
- Review, NA, NA
NRF2↑, COX2↓, IL6↓, IL8↓, IL1↓, iNOS↓, MPO↓, TNF-α↓, VEGF↓, Hif1a↓, p‑AMPK↑,
1158- And,  GEM,    Andrographolide causes apoptosis via inactivation of STAT3 and Akt and potentiates antitumor activity of gemcitabine in pancreatic cancer
TumCP↓, TumCCA↑, Apoptosis↑, STAT3↓, Akt↓, P21↑, BAX↑, cycD1/CCND1↓, cycE/CCNE↓, survivin↓, XIAP↓, Bcl-2↓, eff↑,
1157- And,    Andrographolide suppresses the migratory ability of human glioblastoma multiforme cells by targeting ERK1/2-mediated matrix metalloproteinase-2 expression
- in-vitro, GBM, GBM8401 - in-vitro, GBM, U251
TumCI↓, TumCMig↓, MMP2↓, ERK↝,
1156- And,    Exploring the potential of Andrographis paniculata for developing novel HDAC inhibitors: an in silico approach
- Analysis, NA, NA
HDAC↓,
1093- And,    Andrographolide attenuates epithelial‐mesenchymal transition induced by TGF‐β1 in alveolar epithelial cells
- in-vitro, Lung, A549
TGF-β↓, TumCMig↓, MMP2↓, MMP9↓, ECM/TCF↓, p‑SMAD2↓, p‑SMAD3↓, SMAD4↓, p‑ERK↓, ROS↓, NOX4↓, SOD2↑, SIRT1↑, FOXO3↑,
1078- And,    Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, HUVECs - in-vivo, BC, MCF-7 - in-vitro, BC, T47D - in-vitro, BC, BT549 - in-vitro, BC, MDA-MB-361
TumCP↓, COX2↓, *angioG↓, Cyt‑c↑, CREB2↓, cFos↓, NF-kB↓, HATs↓, cl‑Casp3↑, cl‑Casp9↑, Bax:Bcl2↑, Apoptosis↑, *toxicity↓,
1009- And,  5-FU,    Andrographis-mediated chemosensitization through activation of ferroptosis and suppression of β-catenin/Wnt-signaling pathways in colorectal cancer
- in-vivo, CRC, HCT116 - in-vitro, CRC, SW480
ChemoSen↑, Casp9↑, Ferroptosis↑, Wnt/(β-catenin)↓, FTL↑, TP53↑, ACSL5↑, GCLC↑, GCLM↑, SAT1↑, STEAP3↑, ACSL5↑,
1007- And,    In vitro and in silico evaluation of Andrographis paniculata ethanolic crude extracts on fatty acid synthase expression on breast cancer cells
- in-vitro, BC, MCF-7 - in-vitro, BC, EMT6
tumCV↓, i-FASN↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 19

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

DJ-1↓, 1,   Ferroptosis↑, 2,   GCLC↑, 1,   GCLM↑, 1,   GPx4↓, 1,   GSH↓, 1,   Iron↑, 1,   MDA↑, 1,   MPO↓, 1,   NOX4↓, 1,   NRF2↑, 1,   ROS↓, 1,   ROS↑, 6,   SOD2↑, 1,   xCT↓, 1,  

Metal & Cofactor Biology ⓘ

FTL↑, 1,   STEAP3↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   MMP↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

ACSL5↑, 2,   p‑AMPK↑, 1,   i-FASN↓, 1,   SAT1↑, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 6,   BAX↑, 4,   Bax:Bcl2↑, 1,   Bcl-2↓, 2,   Casp3↑, 1,   cl‑Casp3↑, 1,   Casp9↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↑, 1,   Ferroptosis↑, 2,   iNOS↓, 1,   survivin↓, 1,  

Transcription & Epigenetics ⓘ

HATs↓, 1,   tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↑, 2,   HSP90↓, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

DNA Damage & Repair ⓘ

TP53↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   P21↑, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State ⓘ

cFos↓, 1,   CREB2↓, 1,   ERK↝, 1,   p‑ERK↓, 1,   FOXM1↓, 1,   FOXO3↑, 1,   Gli1↓, 1,   HDAC↓, 1,   HH↓, 1,   mTOR↓, 1,   PI3K↓, 1,   Smo↓, 1,   STAT3↓, 2,   TumCG↓, 2,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

Ki-67↓, 1,   MMP2↓, 2,   MMP9↓, 1,   p‑SMAD2↓, 1,   p‑SMAD3↓, 1,   SMAD4↓, 1,   TGF-β↓, 1,   TumCI↓, 1,   TumCMig↓, 2,   TumCP↓, 3,   TumMeta↓, 1,  

Angiogenesis & Vasculature ⓘ

ECM/TCF↓, 1,   Hif1a↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   IL1↓, 1,   IL6↓, 1,   IL8↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors ⓘ

ERα/ESR1↓, 2,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 3,   eff↓, 1,   eff↑, 4,  

Clinical Biomarkers ⓘ

ERα/ESR1↓, 2,   FOXM1↓, 1,   IL6↓, 1,   Ki-67↓, 1,   TP53↑, 1,  

Functional Outcomes ⓘ

TumW↓, 1,  
Total Targets: 97

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

Catalase↝, 1,   MDA↓, 1,   ROS↓, 2,   SOD↝, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   NO↓, 1,  

Functional Outcomes ⓘ

toxicity↓, 1,  
Total Targets: 7

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:30  Target#:%  State#:%  Dir#:%
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