Database Query Results : Lapachol, ,

LapC, Lapachol: Click to Expand ⟱
Features:
Lapachol is a natural naphthoquinone originally derived from the heartwood of the lapacho tree (Tabebuia species).

Pathways:

Oxidative Stress and ROS Generation
–Like many quinones, lapachol can undergo redox cycling that generates reactive oxygen species (ROS).
-Oxidative damage to DNA, proteins, and lipids, thereby promoting cancer cell death.
-cell cycle at specific checkpoints (commonly at G0/G1 or G2/M phases)
-Inhibition of the NF‑κB signaling pathway
–MAPK Pathways

-ic50 cancer cells 10-50uM, normal cells higher (existence of a therapeutic window)
Scientific Papers found: Click to Expand⟱

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 0

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Total Targets: 0

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:300  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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