Database Query Results : borneol, ,

born, borneol: Click to Expand ⟱
Features:
Borneol is a bicyclic organic compound and a type of monoterpenoid that occurs naturally in various essential oils.
-Recent studies have been exploring borneol’s ability to enhance drug delivery—especially across the blood-brain barrier.
-Borneol is particularly known for its ability to act as a penetration enhancer. This quality can improve the absorption of various drugs, potentially increasing their efficacy when used in combination with other therapeutic agents.
-Borneol is thought to temporarily open tight junctions between endothelial cells, enhancing drug penetration. It may also downregulate efflux transporters such as P-glycoprotein (P-gp), allowing higher intracellular concentrations of co-administered drugs.

Sources:
-Cinnamomum camphora (camphor tree), its essential oil contains borneol along with camphor.
-Dryobalanops aromatica,Often referred to as the camphor tree in Southeast Asia, its oleoresin is a well-known source of natural borneol.
-Blumea balsamifera


Scientific Papers found: Click to Expand⟱
1948- PL,  born,    Natural borneol serves as an adjuvant agent to promote the cellular uptake of piperlongumine for improving its antiglioma efficacy
- in-vitro, GBM, NA
selectivity↑, ROS↑, BioAv↓, BioAv↑, Apoptosis↑, TumCCA↑, eff↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress

ROS↑, 1,  

Cell Death

Apoptosis↑, 1,  

Cell Cycle & Senescence

TumCCA↑, 1,  

Drug Metabolism & Resistance

BioAv↓, 1,   BioAv↑, 1,   eff↑, 1,   selectivity↑, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:301  Target#:%  State#:%  Dir#:%
wNotes=0 sortOrder:rid,rpid

 

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