Database Query Results : urea, ,

urea, urea: Click to Expand ⟱
Features:
Urea is a small, organic molecule (chemical formula: CO(NH₂)₂) that is the primary nitrogen-containing waste product in mammals. It is produced in the liver through the urea cycle, a metabolic pathway that converts toxic ammonia (a byproduct of protein metabolism) into urea, which is then excreted in urine by the kidneys.

-Urea can act as a solubilizing agent for certain drugs, especially those that might benefit from improved solubility in aqueous environments.
-Presence of urea (as a carrier) increased the aqueous solubility of capsaicin by 3.6-fold compared to pure capsaicin
-Urea disrupts the hydrogen bonding within the water molecules which allows hydrophobic solutes to become solvated in water

-In dermatology, urea is commonly present in creams, lotions, and ointments not only for its moisturizing effects but also for its ability to enhance the absorption of other therapeutic agents.


Scientific Papers found: Click to Expand⟱
2015- CAP,  CUR,  urea,    Anti-cancer Activity of Sustained Release Capsaicin Formulations
- Review, Var, NA
AntiCan↑, TumCG↓, angioG↓, TumMeta↓, BioAv↓, BioAv↓, BioAv↑, selectivity↑, EPR↑, eff↓, ChemoSen↑, Dose∅, Half-Life∅, eff↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Proliferation, Differentiation & Cell State

TumCG↓, 1,  

Migration

TumMeta↓, 1,  

Angiogenesis & Vasculature

angioG↓, 1,   EPR↑, 1,  

Drug Metabolism & Resistance

BioAv↓, 2,   BioAv↑, 1,   ChemoSen↑, 1,   Dose∅, 1,   eff↓, 1,   eff↑, 1,   Half-Life∅, 1,   selectivity↑, 1,  

Functional Outcomes

AntiCan↑, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Total Targets: 0

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:304  Target#:%  State#:%  Dir#:%
wNotes=0 sortOrder:rid,rpid

 

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